舌部脂肪堆积与男性性别、上气道通畅异常及全身肥胖有关。
Fat accumulation in the tongue is associated with male gender, abnormal upper airway patency and whole-body adiposity.
作者信息
Godoy Ivan R B, Martinez-Salazar Edgar Leonardo, Eajazi Alireza, Genta Pedro R, Bredella Miriam A, Torriani Martin
机构信息
Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Pulmonary Division, Heart Institute (InCor), Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, SP, Brazil.
出版信息
Metabolism. 2016 Nov;65(11):1657-1663. doi: 10.1016/j.metabol.2016.08.008. Epub 2016 Sep 2.
OBJECTIVE
To examine associations between tongue adiposity with upper airway measures, whole-body adiposity and gender. We hypothesized that increased tongue adiposity is higher in males and positively associated with abnormal upper airway measures and whole-body adiposity.
METHODS
We studied subjects who underwent whole-body positron emission tomography/computed tomography to obtain tongue attenuation (TA) values and cross-sectional area, pharyngeal length (PL) and mandibular plane to hyoid distance (MPH), as well as abdominal circumference, abdominal subcutaneous and visceral (VAT) adipose tissue areas, neck circumference (NC) and neck adipose tissue area. Metabolic syndrome was determined from available clinical and laboratory data.
RESULTS
We identified 206 patients (104 females, 102 males) with mean age 56±17years and mean body mass index (BMI) 28±6kg/m (range 16-47kg/m). Males had lower TA values (P=0.0002) and higher upper airway measures (P<0.0001) independent of age and BMI (P<0.001). In all subjects, TA was negatively associated with upper airway measures (P<0.001). TA was negatively associated with body composition parameters (all P<0.0001), most notably with VAT (r=-0.53) and NC (r=-0.47). TA values were lower in subjects with metabolic syndrome (P<0.0001).
CONCLUSION
Increased tongue adiposity is influenced by gender and is associated with abnormal upper airway patency and body composition parameters.
目的
研究舌部脂肪堆积与上气道测量指标、全身脂肪堆积及性别的相关性。我们假设男性舌部脂肪堆积增加更为明显，且与上气道异常测量指标及全身脂肪堆积呈正相关。
方法
我们对接受全身正电子发射断层扫描/计算机断层扫描的受试者进行研究，以获取舌部衰减（TA）值、横截面积、咽部长度（PL）、下颌平面至舌骨距离（MPH），以及腹围、腹部皮下和内脏（VAT）脂肪组织面积、颈围（NC）和颈部脂肪组织面积。根据现有的临床和实验室数据确定代谢综合征。
结果
我们纳入了206例患者（104例女性，102例男性），平均年龄56±17岁，平均体重指数（BMI）为28±6kg/m²（范围16 - 47kg/m²）。男性的TA值较低（P = 0.0002），上气道测量指标较高（P < 0.0001），且不受年龄和BMI影响（P < 0.001）。在所有受试者中，TA与上气道测量指标呈负相关（P < 0.001）。TA与身体成分参数呈负相关（均P < 0.0001），最显著的是与VAT（r = -0.53）和NC（r = -0.47）。代谢综合征患者的TA值较低（P < 0.0001）。
结论
舌部脂肪堆积增加受性别影响，且与上气道通畅异常及身体成分参数相关。
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