内源性抗菌肽的强效诱导剂用于感染的宿主定向治疗。
Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections.
机构信息
Department of Biosciences and Nutrition, Karolinska Institutet, S-14183, Huddinge, Sweden.
Department of Laboratory Medicine, Karolinska Institutet, S-14186, Huddinge, Sweden.
出版信息
Sci Rep. 2016 Nov 9;6:36692. doi: 10.1038/srep36692.
A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of Shigellosis resulted in recovery from the infection in a few days implying that APD's are promising candidates for treatment of infections.
一种治疗感染的新概念是诱导我们自身的抗菌肽，而所提出的新型诱导剂，芳酰化苯二胺（APD），可在体外将人抗菌肽 LL-37 的诱导倍数提高至 20 至 30 倍。此外，在志贺菌病兔模型中口服 APD 可在数天内从感染中恢复，这表明 APD 是治疗感染的有前途的候选药物。
Zotero 插件