L-脯氨酸、γ-氨基丁酸合成与精神分裂症中的γ振荡
l-Proline, GABA Synthesis and Gamma Oscillations in Schizophrenia.
作者信息
Volk David W, Gonzalez-Burgos Guillermo, Lewis David A
机构信息
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
出版信息
Trends Neurosci. 2016 Dec;39(12):797-798. doi: 10.1016/j.tins.2016.10.009. Epub 2016 Nov 8.
Abstract
Altered inhibition from parvalbumin-containing GABA neurons is thought to contribute to impaired gamma frequency oscillations and cognitive deficits in schizophrenia. Crabtree and colleagues report that proline dehydrogenase deficits produce excessive cytosolic levels of the GABA-mimetic l-proline which impairs GABA synthesis and gamma oscillations in a manner that mimics schizophrenia.
摘要
含小白蛋白的γ-氨基丁酸（GABA）神经元的抑制作用改变被认为是导致精神分裂症患者γ频率振荡受损和认知缺陷的原因。克拉布特里及其同事报告称，脯氨酸脱氢酶缺乏会使细胞溶质中GABA模拟物L-脯氨酸水平过高，从而以类似于精神分裂症的方式损害GABA合成和γ振荡。
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本文引用的文献
1
Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade.
Cell Rep. 2016 Oct 4;17(2):570-582. doi: 10.1016/j.celrep.2016.09.029.
2
Frontal Glutamate and γ-Aminobutyric Acid Levels and Their Associations With Mismatch Negativity and Digit Sequencing Task Performance in Schizophrenia.
JAMA Psychiatry. 2016 Feb;73(2):166-74. doi: 10.1001/jamapsychiatry.2015.2680.
3
Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia.
Biol Psychiatry. 2015 Jun 15;77(12):1031-40. doi: 10.1016/j.biopsych.2015.03.010. Epub 2015 Mar 17.
4
Lower glutamic acid decarboxylase 65-kDa isoform messenger RNA and protein levels in the prefrontal cortex in schizoaffective disorder but not schizophrenia.
Biol Psychiatry. 2015 Jan 15;77(2):167-76. doi: 10.1016/j.biopsych.2014.05.010. Epub 2014 May 29.
5
GAD67 deficiency in parvalbumin interneurons produces deficits in inhibitory transmission and network disinhibition in mouse prefrontal cortex.
Cereb Cortex. 2015 May;25(5):1290-6. doi: 10.1093/cercor/bht322. Epub 2013 Nov 24.
6
Deficits in transcriptional regulators of cortical parvalbumin neurons in schizophrenia.
Am J Psychiatry. 2012 Oct;169(10):1082-91. doi: 10.1176/appi.ajp.2012.12030305.
7
Cortical deficits of glutamic acid decarboxylase 67 expression in schizophrenia: clinical, protein, and cell type-specific features.
Am J Psychiatry. 2011 Sep;168(9):921-9. doi: 10.1176/appi.ajp.2011.11010052. Epub 2011 Jun 1.
8
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance.
Nature. 2009 Jun 4;459(7247):698-702. doi: 10.1038/nature07991. Epub 2009 Apr 26.
9
Impairments in frontal cortical gamma synchrony and cognitive control in schizophrenia.
Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19878-83. doi: 10.1073/pnas.0609440103. Epub 2006 Dec 14.
10
The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid release.
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12911-6. doi: 10.1073/pnas.96.22.12911.
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