病原体相关分子模式（PAMPs）在真菌感染免疫应答中的作用。
Role of pathogen-associated molecular patterns (PAMPS) in immune responses to fungal infections.
作者信息
Taghavi Mehdi, Khosravi Alireza, Mortaz Esmaeil, Nikaein Donya, Athari Seyyed Shamsadin
机构信息
Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Eur J Pharmacol. 2017 Aug 5;808:8-13. doi: 10.1016/j.ejphar.2016.11.013. Epub 2016 Nov 14.
Recent years have seen the rise of invasive fungal infections, which are mostly due to the increase in patients. Three major opportunistic fungal species in human are Aspergillus fumigatus, Candida albicans, and Cryptococcus neoformans that pose the biggest concern for these immunocompromised patients' mortality. The growing occurrence of opportunistic fungal infections has sparked the interest to understand defense mechanisms against pathogenic fungi. Toll-like receptors (TLRs), as a part of innate immune system, play an important role for recognizing the invading microorganisms and initiating sufficient immune responses. Recent studies have revealed an integrated role for TLR, signaling inactivating immune defense mechanisms against exact fungi. Among TLRs, TLR2 and TLR4 are the major participants in fungi recognition. The present paper highlights the role of TLR participants in fungal recognition as well as their mechanisms.
近年来，侵袭性真菌感染有所增加，这主要是由于患者数量的增多。人类的三种主要机会性真菌物种是烟曲霉、白色念珠菌和新型隐球菌，它们是这些免疫功能低下患者死亡的最大担忧因素。机会性真菌感染的日益增多引发了人们对了解抗致病真菌防御机制的兴趣。Toll样受体（TLRs）作为固有免疫系统的一部分，在识别入侵微生物和启动充分免疫反应方面发挥着重要作用。最近的研究揭示了TLR信号在针对特定真菌的免疫防御机制失活中的综合作用。在TLRs中，TLR2和TLR4是真菌识别的主要参与者。本文重点介绍了TLR参与者在真菌识别中的作用及其机制。
Zotero 插件