蛇床子素与黄芩苷联合使用可保护小鼠免受金黄色葡萄球菌肺炎的侵害。
The combination of osthole with baicalin protects mice from Staphylococcus aureus pneumonia.
作者信息
Liu Shui, Liu Bowen, Luo Zhao-Qing, Qiu Jiaming, Zhou Xuan, Li Gen, Zhang Bing, Deng Xuming, Yang Zhenguo, Wang Jianfeng
机构信息
Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
出版信息
World J Microbiol Biotechnol. 2017 Jan;33(1):11. doi: 10.1007/s11274-016-2162-9. Epub 2016 Nov 23.
We reported the inhibition of α-Hemolysin (Hla) production in methicillin-resistant Staphylococcus aureus USA300 by osthole and further investigated the combination of osthole and baicalin in the treatment of staphylococcal pneumonia. Using cytotoxicity assays and a mouse model of intranasal lung infection, we evaluated the effect of combined therapy. Our results suggest that the combination of osthole and baicalin alleviated S. aureus-mediated A549 cell injury and protected mice from S. aureus pneumonia.
我们报道了蛇床子素对耐甲氧西林金黄色葡萄球菌USA300中α-溶血素（Hla）产生的抑制作用，并进一步研究了蛇床子素与黄芩苷联合治疗葡萄球菌肺炎的效果。通过细胞毒性试验和鼻内肺部感染小鼠模型，我们评估了联合治疗的效果。我们的结果表明，蛇床子素与黄芩苷联合使用可减轻金黄色葡萄球菌介导的A549细胞损伤，并保护小鼠免受金黄色葡萄球菌肺炎的侵害。
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