成人急性髓系白血病的诊断与管理：2017年国际专家小组的欧洲白血病网络（ELN）建议
Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel.
作者信息
Döhner Hartmut, Estey Elihu, Grimwade David, Amadori Sergio, Appelbaum Frederick R, Büchner Thomas, Dombret Hervé, Ebert Benjamin L, Fenaux Pierre, Larson Richard A, Levine Ross L, Lo-Coco Francesco, Naoe Tomoki, Niederwieser Dietger, Ossenkoppele Gert J, Sanz Miguel, Sierra Jorge, Tallman Martin S, Tien Hwei-Fang, Wei Andrew H, Löwenberg Bob, Bloomfield Clara D
机构信息
Department of Internal Medicine III, University of Ulm, Ulm, Germany.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
出版信息
Blood. 2017 Jan 26;129(4):424-447. doi: 10.1182/blood-2016-08-733196. Epub 2016 Nov 28.
The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults, published in 2010, has found broad acceptance by physicians and investigators caring for patients with AML. Recent advances, for example, in the discovery of the genomic landscape of the disease, in the development of assays for genetic testing and for detecting minimal residual disease (MRD), as well as in the development of novel antileukemic agents, prompted an international panel to provide updated evidence- and expert opinion-based recommendations. The recommendations include a revised version of the ELN genetic categories, a proposal for a response category based on MRD status, and criteria for progressive disease.
欧洲白血病网络（ELN）发布的首版成人急性髓系白血病（AML）诊断与管理建议于2010年问世，已获得诊治AML患者的医生和研究人员的广泛认可。例如，该疾病基因组图谱的发现、基因检测及微小残留病（MRD）检测方法的开发以及新型抗白血病药物的研发等近期进展，促使一个国际专家小组提供基于证据和专家意见的更新建议。这些建议包括ELN基因分类的修订版、基于MRD状态的缓解分类提议以及疾病进展标准。
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