子宫内膜癌：特定的靶向通路

Endometrial Carcinoma: Specific Targeted Pathways.

作者信息

Eritja Nuria, Yeramian Andree, Chen Bo-Juen, Llobet-Navas David, Ortega Eugenia, Colas Eva, Abal Miguel, Dolcet Xavier, Reventos Jaume, Matias-Guiu Xavier

机构信息

Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLLEIDA, Av Rovira Roure, 80, 25198, Lleida, Spain.

GEICEN Research Group, Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLLEIDA, Av Rovira Roure, 80, 25198, Lleida, Spain.

出版信息

Adv Exp Med Biol. 2017;943:149-207. doi: 10.1007/978-3-319-43139-0_6.

DOI:10.1007/978-3-319-43139-0_6

PMID:27910068

Abstract

Endometrial cancer (EC) is the most common gynecologic malignancy in the western world with more than 280,000 cases per year worldwide. Prognosis for EC at early stages, when primary surgical resection is the most common initial treatment, is excellent. Five-year survival rate is around 70 %.Several molecular alterations have been described in the different types of EC. They occur in genes involved in important signaling pathways. In this chapter, we will review the most relevant altered pathways in EC, including PI3K/AKT/mTOR, RAS-RAF-MEK-ERK, Tyrosine kinase, WNT/β-Catenin, cell cycle, and TGF-β signaling pathways. At the end of the chapter, the most significant clinical trials will be briefly discussed.This information is important to identify specific targets for therapy.

摘要

子宫内膜癌（EC）是西方世界最常见的妇科恶性肿瘤，全球每年有超过28万例病例。早期子宫内膜癌的预后良好，此时初次手术切除是最常见的初始治疗方法。五年生存率约为70%。在不同类型的子宫内膜癌中已发现多种分子改变。这些改变发生在参与重要信号通路的基因中。在本章中，我们将回顾子宫内膜癌中最相关的改变通路，包括PI3K/AKT/mTOR、RAS-RAF-MEK-ERK、酪氨酸激酶、WNT/β-连环蛋白、细胞周期和TGF-β信号通路。本章末尾将简要讨论最重要的临床试验。这些信息对于确定特定的治疗靶点很重要。