癌症中的环状RNA：一个新兴的关键角色。
Circular RNAs in cancer: an emerging key player.
作者信息
Dong Yeping, He Dan, Peng Zhenzi, Peng Wei, Shi Wenwen, Wang Jun, Li Bin, Zhang Chunfang, Duan Chaojun
机构信息
Institute of Medical Sciences, Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, 410008, Hunan, People's Republic of China.
Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, 410008, Hunan, People's Republic of China.
出版信息
J Hematol Oncol. 2017 Jan 3;10(1):2. doi: 10.1186/s13045-016-0370-2.
Circular RNAs (circRNAs) are a class of endogendous RNAs that form a covalently closed continuous loop and exist extensively in mammalian cells. Majority of circRNAs are conserved across species and often show tissue/developmental stage-specific expression. CircRNAs were first thought to be the result of splicing error; however, subsequent research shows that circRNAs can function as microRNA (miRNA) sponges and regulate splicing and transcription. Emerging evidence shows that circRNAs possess closely associated with human diseases, especially cancers, and may serve as better biomarkers. After miRNA and long noncoding RNA (lncRNA), circRNAs are becoming a new hotspot in the field of RNA of cancer. Here, we review biogenesis and metabolism of circRNAs, their functions, and potential roles in cancer.
环状RNA（circRNAs）是一类内源性RNA，其形成共价闭合的连续环，广泛存在于哺乳动物细胞中。大多数circRNAs在物种间保守，且常表现出组织/发育阶段特异性表达。circRNAs最初被认为是剪接错误的结果；然而，后续研究表明，circRNAs可作为微小RNA（miRNA）海绵发挥作用，并调节剪接和转录。新出现的证据表明，circRNAs与人类疾病尤其是癌症密切相关，可能是更好的生物标志物。继miRNA和长链非编码RNA（lncRNA）之后，circRNAs正成为癌症RNA领域的一个新热点。在此，我们综述circRNAs的生物发生和代谢、其功能以及在癌症中的潜在作用。
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