塞内加尔达喀尔恶性疟原虫中Pf基因多态性与对奎宁敏感性之间的关联
Association between Polymorphisms in the Pf Gene and Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal.
作者信息
Gendrot Mathieu, Diawara Silman, Madamet Marylin, Kounta Mame Bou, Briolant Sébastien, Wade Khalifa Ababacar, Fall Mansour, Benoit Nicolas, Nakoulima Aminata, Amalvict Rémy, Diémé Yaya, Fall Bécaye, Wade Boubacar, Diatta Bakary, Pradines Bruno
机构信息
Unité de Parasitologie et d'Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France.
Aix Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France.
出版信息
Antimicrob Agents Chemother. 2017 Feb 23;61(3). doi: 10.1128/AAC.01183-16. Print 2017 Mar.
Abstract
Polymorphisms and the overexpression of transporter genes, especially of the ATP-binding cassette superfamily, have been involved in antimalarial drug resistance. The objective of this study was to use 77 Senegalese isolates to evaluate the association between the number of Asn residues in the polymorphic microsatellite region of the multidrug resistance 6 gene (Pf) and the susceptibility to antimalarials. A significant association was observed between the presence of 7 or 9 Asn repeats and reduced susceptibility to quinine.
摘要
多态性以及转运蛋白基因（尤其是ATP结合盒超家族基因）的过表达与抗疟药耐药性有关。本研究的目的是使用77株塞内加尔分离株，评估多药耐药6基因（Pf）多态性微卫星区域中天冬酰胺（Asn）残基数量与对抗疟药敏感性之间的关联。观察到存在7个或9个Asn重复序列与对奎宁的敏感性降低之间存在显著关联。
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