早年暴露于饥荒与青岛成年人肥胖风险：来自1959 - 1961年中国饥荒的证据

Exposure to famine in early life and the risk of obesity in adulthood in Qingdao: Evidence from the 1959-1961 Chinese famine.

作者信息

Liu L, Pang Z C, Sun J P, Xue B, Wang S J, Ning F, Qiao Q

机构信息

Department of Nutrition and Food Hygiene, Qingdao University Medical College, Qingdao 266021, Shandong Province, China; Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, Shandong Province, China.

出版信息

Nutr Metab Cardiovasc Dis. 2017 Feb;27(2):154-160. doi: 10.1016/j.numecd.2016.11.125. Epub 2016 Dec 5.

DOI:10.1016/j.numecd.2016.11.125

PMID:28081988

Abstract

BACKGROUND AND AIMS

We aimed to evaluate the association between famine exposure during early life and obesity and obesity (obese at the highest weight) in adulthood.

METHODS AND RESULTS

Data were from two population-based cross-sectional surveys conducted in 2006 and 2009 in Qingdao, China. A total of 8185 subjects born between 1/1/1941 and 12/31/1971 were categorized into unexposed (born between 01/01/1962 and 12/31/1971), fetal/infant exposed (born between 01/01/1959 and 12/31/1961), childhood exposed (born between 01/01/1949 and 12/31/1958) and adolescence exposed (born between 01/01/1941 and 12/31/1948) according to their age when exposed to the Chinese famine from 1959 to 1961. Obesity was defined as BMI (body mass index) ≥28.0 and obesity was defined as BMI (BMI at the highest weight) ≥28.0. We compared fetal/infant exposed, childhood exposed and adolescence exposed to the unexposed using logistic regression models to assess the effect of famine exposure on later obesity and obesity. Fetal/infant exposed (OR = 1.59, P < 0.001), childhood exposed (OR = 1.42, P < 0.01) and adolescence exposed (OR = 1.86, P < 0.01) all had higher risks of obesity than the unexposed. Exposure groups were more likely to be obese at their highest weight than the unexposed, and ORs (95%CIs) for obesity in the fetal/infant exposed, childhood exposed and adolescence exposed were 1.49(1.20-1.86), 1.24(1.02-1.49) and 1.64 (1.40-1.93), respectively. Similar results were found in both men and women.

CONCLUSION

Exposure to famine in early life was associated with increased risks of obesity and obesity in adulthood. Preventing undernutrition in early life appears beneficial to reduce the prevalence of later obesity.

摘要

背景与目的

我们旨在评估生命早期暴露于饥荒与成年期肥胖及超重（最高体重时肥胖）之间的关联。

方法与结果

数据来自2006年和2009年在中国青岛进行的两项基于人群的横断面调查。共有8185名出生于1941年1月1日至1971年12月31日之间的受试者，根据他们在1959年至1961年中国饥荒期间的暴露年龄，被分为未暴露组（出生于1962年1月1日至1971年12月31日）、胎儿/婴儿暴露组（出生于1959年1月1日至1961年12月31日）、儿童暴露组（出生于1949年1月1日至1958年12月31日）和青少年暴露组（出生于1941年1月1日至1948年12月31日）。肥胖定义为体重指数（BMI）≥28.0，超重定义为最高体重时的BMI≥28.0。我们使用逻辑回归模型比较胎儿/婴儿暴露组、儿童暴露组和青少年暴露组与未暴露组，以评估饥荒暴露对后期肥胖及超重的影响。胎儿/婴儿暴露组（比值比[OR]=1.59，P<0.001）、儿童暴露组（OR=1.42，P<0.01）和青少年暴露组（OR=1.86，P<0.01）的肥胖风险均高于未暴露组。暴露组在最高体重时肥胖的可能性高于未暴露组，胎儿/婴儿暴露组、儿童暴露组和青少年暴露组超重的OR（95%置信区间）分别为1.49（1.20 - 1.86）、1.24（1.02 - 1.49）和1.64（1.40 - 1.93）。在男性和女性中均发现了类似结果。