子孢子生物学
Sporozoite Biology.
作者信息
Frischknecht Friedrich, Matuschewski Kai
机构信息
Integrative Parasitology, Center for Infectious Diseases, University of Heidelberg Medical School, 69120 Heidelberg, Germany.
Department of Molecular Parasitology, Institute of Biology, Humboldt University Berlin, 10115 Berlin, Germany.
出版信息
Cold Spring Harb Perspect Med. 2017 May 1;7(5):a025478. doi: 10.1101/cshperspect.a025478.
Abstract
sporozoite transmission is a critical population bottleneck in parasite life-cycle progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of a candidate antisporozoite subunit vaccine formulation to licensure highlights the importance of sporozoite transmission intervention in the malaria control portfolio. Sporozoites colonize mosquito salivary glands, migrate through the skin, penetrate blood vessels, breach the liver sinusoid, and invade hepatocytes. Understanding the molecular and cellular mechanisms that mediate the remarkable sporozoite journey in the invertebrate vector and the vertebrate host can inform evidence-based next-generation drug development programs and immune intervention strategies.
摘要
子孢子传播是寄生虫生命周期进展中的一个关键种群瓶颈，因此是预防性药物和疫苗的靶点。一种候选抗子孢子亚单位疫苗制剂近期取得的上市进展凸显了子孢子传播干预在疟疾控制方案中的重要性。子孢子定殖于蚊子唾液腺，穿过皮肤迁移，穿透血管，突破肝血窦，并侵入肝细胞。了解介导子孢子在无脊椎动物载体和脊椎动物宿主中非凡旅程的分子和细胞机制，可为基于证据的下一代药物开发计划和免疫干预策略提供依据。
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