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撤稿声明:李J、王J、王Y、邱H所著的“MicroRNA-218通过靶向Rictor增加宫颈癌对雷帕霉素的细胞敏感性”

Retraction Statement: 'MicroRNA-218 increases cellular sensitivity to Rapamycin via targeting Rictor in cervical cancer' by Li J, Wang J, Wang Y, Qiu H.

出版信息

APMIS. 2017 Feb;125(2):176. doi: 10.1111/apm.12644. Epub 2016 Dec 2.

Abstract

The above article from APMIS, published online on 24 April 2015 in Wiley Online Library (wileyonlinelibrary.com) and in Volume 123, pp. 562-570, has been retracted by agreement between the authors, the journal Editors in Chief, Professors Bodil Norrild, Ben Vainer and Elisabeth Ralfkiaer, and John Wiley & Sons Ltd. The article has been retracted due to errors in the reported results. In this study, the authors used HeLa and SiHa cell lines to investigate the biological roles of miR-218. However, subsequently it emerged that the two cell lines were contaminated in the laboratory by other unknown cell lines. When repeating the experiments, it was found that the functions of miR-218 were not as significant as had been previously reported, especially its effects on rapamycin sensitivity. Reference Li J, Li X, Wang J, Wang Y, Qiu H. MicroRNA-218 increases cellular sensitivity to Rapamycin via targeting Rictor in cervical cancer. APMIS 2015; 123:562-570. doi: 10.1111/apm.12387.

摘要

上述发表于《APMIS》的文章,于2015年4月24日在线发表于威利在线图书馆(wileyonlinelibrary.com),载于第123卷,第562 - 570页,经作者、期刊主编博迪尔·诺里尔教授、本·瓦纳教授和伊丽莎白·拉尔夫凯尔教授以及约翰·威利父子有限公司协商一致后予以撤回。该文章因报告结果存在错误而被撤回。在本研究中,作者使用HeLa和SiHa细胞系来研究miR - 218的生物学作用。然而,随后发现这两种细胞系在实验室中被其他未知细胞系污染。在重复实验时,发现miR - 218的功能并不像之前报道的那样显著,尤其是其对雷帕霉素敏感性的影响。参考文献:Li J, Li X, Wang J, Wang Y, Qiu H. MicroRNA - 218 increases cellular sensitivity to Rapamycin via targeting Rictor in cervical cancer. APMIS 2015; 123:562 - 570. doi: 10.1111/apm.12387.

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