在黑暗中奋勇前行：增殖细胞核抗原，依然是复制叉处的主要指挥者。
Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork.
作者信息
Choe Katherine N, Moldovan George-Lucian
机构信息
Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
出版信息
Mol Cell. 2017 Feb 2;65(3):380-392. doi: 10.1016/j.molcel.2016.12.020.
Abstract
Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was originally studied for its role in stimulating DNA polymerases. However, we now know that PCNA does much more than promote processive DNA synthesis. Because of the complexity of the events involved, cellular DNA replication poses major threats to genomic integrity. Whatever predicament lies ahead for the replication fork, PCNA is there to orchestrate the events necessary to handle it. Through its many protein interactions and various post-translational modifications, PCNA has far-reaching impacts on a myriad of cellular functions.
摘要
增殖细胞核抗原（PCNA）处于真核生物基因组忠实复制的核心位置。凭借其独特的甜甜圈状分子结构，PCNA最初因其在刺激DNA聚合酶方面的作用而受到研究。然而，我们现在知道PCNA的作用远不止促进持续性DNA合成。由于所涉及事件的复杂性，细胞DNA复制对基因组完整性构成了重大威胁。无论复制叉面临何种困境，PCNA都会在那里协调处理它所需的各种事件。通过其众多的蛋白质相互作用和各种翻译后修饰，PCNA对无数细胞功能产生深远影响。
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