用于声带组织工程的透明质酸及基于透明质酸的水凝胶综述
A Review of Hyaluronic Acid and Hyaluronic Acid-based Hydrogels for Vocal Fold Tissue Engineering.
作者信息
Walimbe Tanaya, Panitch Alyssa, Sivasankar Preeti M
机构信息
Weldon School of Biomedical Engineering, West Lafayette, Indiana.
Weldon School of Biomedical Engineering, West Lafayette, Indiana; Department of Biomedical Engineering, University of California, Davis, California.
出版信息
J Voice. 2017 Jul;31(4):416-423. doi: 10.1016/j.jvoice.2016.11.014. Epub 2017 Mar 2.
Abstract
Vocal fold scarring is a common cause of dysphonia. Current treatments involving vocal fold augmentation do not yield satisfactory outcomes in the long term. Tissue engineering and regenerative medicine offer an attractive treatment option for vocal fold scarring, with the aim to restore the native extracellular matrix microenvironment and biomechanical properties of the vocal folds by inhibiting progression of scarring and thus leading to restoration of normal vocal function. Hyaluronic acid is a bioactive glycosaminoglycan responsible for maintaining optimum viscoelastic properties of the vocal folds and hence is widely targeted in tissue engineering applications. This review covers advances in hyaluronic acid-based vocal fold tissue engineering and regeneration strategies.
摘要
声带瘢痕化是声音嘶哑的常见原因。目前涉及声带增强的治疗方法长期效果并不理想。组织工程和再生医学为声带瘢痕化提供了一种有吸引力的治疗选择，旨在通过抑制瘢痕化进展来恢复声带的天然细胞外基质微环境和生物力学特性，从而恢复正常的发声功能。透明质酸是一种生物活性糖胺聚糖，负责维持声带的最佳粘弹性，因此在组织工程应用中受到广泛关注。本文综述了基于透明质酸的声带组织工程和再生策略的进展。
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