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氧调节途径中缺氧诱导因子和羟化酶的最新进展:从生理学到治疗学

Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics.

作者信息

Ratcliffe Peter, Koivunen Peppi, Myllyharju Johanna, Ragoussis Jiannis, Bovée Judith Vmg, Batinic-Haberle Ines, Vinatier Claire, Trichet Valérie, Robriquet Florence, Oliver Lisa, Gardie Betty

机构信息

Target Discovery Institute, University of Oxford; The Francis Crick Institute, London, UK.

Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

出版信息

Hypoxia (Auckl). 2017 Mar 15;5:11-20. doi: 10.2147/HP.S127042. eCollection 2017.

Abstract

The "Hypoxia Nantes 2016" organized its second conference dedicated to the field of hypoxia research. This conference focused on "the role of hypoxia under physiological conditions as well as in cancer" and took place in Nantes, France, in October 6-7, 2016. The main objective of this conference was to bring together a large group of scientists from different spheres of hypoxia. Recent advances were presented and discussed around different topics: genomics, physiology, musculoskeletal, stem cells, microenvironment and cancer, and oxidative stress. This review summarizes the major highlights of the meeting.

摘要

“2016年南特缺氧大会”举办了第二届专注于缺氧研究领域的会议。本次会议聚焦于“生理条件下以及癌症中的缺氧作用”,于2016年10月6日至7日在法国南特举行。本次会议的主要目标是汇聚来自缺氧研究不同领域的众多科学家。围绕不同主题展示并讨论了最新进展:基因组学、生理学、肌肉骨骼、干细胞、微环境与癌症以及氧化应激。本综述总结了此次会议的主要亮点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e50f/5359007/cdac46e47328/hp-5-011Fig1.jpg

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