基于 mRNA 的寨卡病毒疫苗策略。
An mRNA-based vaccine strategy against Zika.
机构信息
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China.
出版信息
Cell Res. 2017 Sep;27(9):1077-1078. doi: 10.1038/cr.2017.53. Epub 2017 Apr 11.
Infections with Zika virus are strongly associated with complications such as congenital microcephaly and can trigger Guillain-Barré syndrome in humans, highlighting the urgent need for a safe, efficacious vaccine as a preventative countermeasure. In a recent paper published in Cell, Richner et al. generated a lipid nanoparticle encapsulated modified mRNA vaccine encoding the prM and E genes from Zika virus, which showed protection and sterilizing immunity in immunocompetent mice.
寨卡病毒感染与先天性小头畸形等并发症密切相关，还可引发人类吉兰-巴雷综合征，这凸显了急需安全有效的疫苗作为预防对策。在最近发表于《Cell》的一篇论文中，Richner 等人构建了一种包裹修饰 mRNA 的脂质纳米颗粒疫苗，该疫苗可编码寨卡病毒的 prM 和 E 基因，在免疫功能正常的小鼠中显示出保护和绝育性免疫作用。
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