肝细胞生长因子激活剂是一种损伤调节的全身因子，可诱导干细胞向颗粒细胞转变。
HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G.
作者信息
Rodgers Joseph T, Schroeder Matthew D, Ma Chanthia, Rando Thomas A
机构信息
Glenn Center for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Glenn Center for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
出版信息
Cell Rep. 2017 Apr 18;19(3):479-486. doi: 10.1016/j.celrep.2017.03.066.
The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into G, a cellular state in which they have an increased functional ability to activate and participate in tissue repair. However, the precise molecular signals that induce G in stem cells have remained elusive. Here, we show that the injury-induced regulation of hepatocyte growth factor (HGF) proteolytic processing via the systemic protease, hepatocyte growth factor activator (HGFA), stimulates G in skeletal muscle stem cells (MuSCs) and fibro-adipogenic progenitors (FAPs). We demonstrate that administering active HGFA to animals is sufficient to induce G in stem cells throughout the body and to significantly accelerate the processes of stem cell activation and tissue repair. Our data suggest that factors that induce G will have broad therapeutic applications for regenerative medicine and wound healing.
将静止干细胞激活进入细胞周期是启动组织修复过程的关键步骤。我们最近报道，静止干细胞可以转变为G状态，在此状态下它们激活并参与组织修复的功能能力增强。然而，诱导干细胞进入G状态的确切分子信号仍不清楚。在这里，我们表明，通过全身蛋白酶肝细胞生长因子激活剂（HGFA）对肝细胞生长因子（HGF）进行损伤诱导的蛋白水解加工，可刺激骨骼肌干细胞（MuSCs）和成纤维脂肪生成祖细胞（FAPs）进入G状态。我们证明，给动物施用活性HGFA足以诱导全身干细胞进入G状态，并显著加速干细胞激活和组织修复过程。我们的数据表明，诱导G状态的因子在再生医学和伤口愈合方面将具有广泛的治疗应用。
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