基因体DNA甲基化与H3K36me3协同作用以防止异常转录。
Gene body DNA methylation conspires with H3K36me3 to preclude aberrant transcription.
作者信息
Teissandier Aurélie, Bourc'his Déborah
机构信息
"Epigenetic Decisions and Reproduction" Group, Institut Curie, PSL University, CNRS, INSERM, Paris, France.
出版信息
EMBO J. 2017 Jun 1;36(11):1471-1473. doi: 10.15252/embj.201796812. Epub 2017 Apr 25.
Abstract
DNA methylation of promoters is well known for its repressive effect on transcription initiation of protein‐coding genes, non‐coding RNAs, or transposon repeats. However, gene bodies represent the most conserved targets of DNA methylation among eukaryotes, and yet the function of intragenic methylation remains unclear. Recent research (Neri , 2017) suggests that intragenic methylation may serve to confine transcription initiation to canonical promoters in embryonic stem cells, thus preventing the production of aberrant transcripts.
摘要
启动子的DNA甲基化因其对蛋白质编码基因、非编码RNA或转座子重复序列转录起始的抑制作用而广为人知。然而，基因体是真核生物中DNA甲基化最保守的靶点，但其基因内甲基化的功能仍不清楚。最近的研究（Neri，2017）表明，基因内甲基化可能有助于将转录起始限制在胚胎干细胞的典型启动子上，从而防止异常转录本的产生。
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