纳米植物囊泡：癌症治疗中用于草药抗癌剂的新兴平台。
Nano-Phytosome: A Developing Platform for Herbal Anti-Cancer Agents in Cancer Therapy.
机构信息
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Food Science and Technology, Ferdowsi University of Mashhad, Mashhad, Iran.
出版信息
Curr Drug Targets. 2018;19(2):170-180. doi: 10.2174/1389450118666170508095250.
BACKGROUND
Cancer is one of the main causes of death in the world. It has not yet been cured in an efficient manner and has remained a major challenge for current chemotherapy.
OBJECTIVE
This review summarizes the latest investigations regarding the possible application of phytosome complexes for cancer therapy, their formulation techniques, and mechanism of transportation through phytosome.
RESULTS
Nanotechnology opened a pioneer field in cancer therapy by modifying significant properties of drugs and their carriers. Nanotechnology utilizes various nanostructures to transport anti-cancer agents to the site of action. The greater stability of nanophytosomes is due to formation of chemical links between phospholipid molecules and phytoactive agents. Among several new drug delivery systems, phytosomes depict an advanced technology to deliver phytoactive compounds to the target site of action, and at present, several phytosome formulations are in clinical use.
CONCLUSION
Potential anti-cancer properties of phytoconstituents are enhanced by phytosomal formulations.
背景
癌症是世界上主要的死亡原因之一。目前还没有有效的治疗方法，仍然是当前化疗的主要挑战。
目的
本综述总结了关于植物甾醇复合物在癌症治疗中的可能应用、制剂技术以及通过植物甾醇运输的机制的最新研究进展。
结果
纳米技术通过修饰药物及其载体的重要特性，为癌症治疗开辟了一个先锋领域。纳米技术利用各种纳米结构将抗癌药物输送到作用部位。纳米植物甾醇体的稳定性更高，这是由于磷脂分子和植物活性成分之间形成了化学连接。在几种新的药物传递系统中，植物甾醇体描绘了一种将植物活性化合物递送到作用部位的先进技术，目前有几种植物甾醇体制剂正在临床使用。
结论
植物甾醇体制剂增强了植物成分的潜在抗癌特性。
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