TGF-β 家族信号在间充质分化中的作用。
TGF-β Family Signaling in Mesenchymal Differentiation.
机构信息
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030.
Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109.
出版信息
Cold Spring Harb Perspect Biol. 2018 May 1;10(5):a022202. doi: 10.1101/cshperspect.a022202.
Abstract
Mesenchymal stem cells (MSCs) can differentiate into several lineages during development and also contribute to tissue homeostasis and regeneration, although the requirements for both may be distinct. MSC lineage commitment and progression in differentiation are regulated by members of the transforming growth factor-β (TGF-β) family. This review focuses on the roles of TGF-β family signaling in mesenchymal lineage commitment and differentiation into osteoblasts, chondrocytes, myoblasts, adipocytes, and tenocytes. We summarize the reported findings of cell culture studies, animal models, and interactions with other signaling pathways and highlight how aberrations in TGF-β family signaling can drive human disease by affecting mesenchymal differentiation.
摘要
间充质干细胞（MSCs）在发育过程中可以分化为几种谱系，也有助于组织稳态和再生，尽管两者的要求可能不同。MSC 谱系的决定和分化过程中的进展受转化生长因子-β（TGF-β）家族成员的调节。本综述重点介绍了 TGF-β家族信号在间充质谱系决定和向成骨细胞、软骨细胞、成肌细胞、脂肪细胞和成纤维细胞分化中的作用。我们总结了细胞培养研究、动物模型的报道结果以及与其他信号通路的相互作用，并强调了 TGF-β家族信号的异常如何通过影响间充质分化来驱动人类疾病。
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