Wnt/β-连环蛋白信号通路、疾病与新兴治疗模式。

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

机构信息

Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Hubrecht Institute, University Medical Center Utrecht, Princess Maxima Center for Pediatric Oncology, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.

出版信息

Cell. 2017 Jun 1;169(6):985-999. doi: 10.1016/j.cell.2017.05.016.

DOI:10.1016/j.cell.2017.05.016

PMID:28575679

Abstract

The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

摘要

WNT 信号转导级联是动物界发育的主要调节剂。Wnts 也是成年哺乳动物大多数类型组织干细胞的关键驱动因素。毫不奇怪，突变的 Wnt 途径成分是多种与生长相关的病理和癌症的原因。在这里，我们描述了核心的 Wnt/β-连环蛋白信号通路，它如何控制干细胞，并有助于疾病。最后，我们讨论了基于 Wnt 的治疗策略。