阴道念珠菌属基因组来自患有外阴阴道念珠菌病的女性。
Vaginal Candida spp. genomes from women with vulvovaginal candidiasis.
机构信息
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201 USA.
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
出版信息
Pathog Dis. 2017 Aug 31;75(6). doi: 10.1093/femspd/ftx061.
Abstract
Candida albicans is the predominant cause of vulvovaginal candidiasis (VVC). Little is known regarding the genetic diversity of Candida spp. in the vagina or the microvariations in strains over time that may contribute to the development of VVC. This study reports the draft genome sequences of four C. albicans and one C. glabrata strains isolated from women with VVC. An SNP-based whole-genome phylogeny indicates that these isolates are closely related; however, phylogenetic distances between them suggest that there may be genetic adaptations driven by unique host environments. These sequences will facilitate further comparative analyses and ultimately improve our understanding of genetic variation in isolates of Candida spp. that are associated with VVC.
摘要
白色念珠菌是外阴阴道念珠菌病（VVC）的主要病原体。目前对于阴道内念珠菌属的遗传多样性以及可能导致 VVC 的菌株随时间的微小变化知之甚少。本研究报告了从患有 VVC 的女性中分离出的 4 株白色念珠菌和 1 株光滑念珠菌的基因组序列草案。基于 SNP 的全基因组系统发育分析表明，这些分离株密切相关；然而，它们之间的系统发育距离表明，可能存在由独特的宿主环境驱动的遗传适应性。这些序列将有助于进一步的比较分析，并最终提高我们对与 VVC 相关的念珠菌属分离株遗传变异的理解。
相似文献
1
Vaginal Candida spp. genomes from women with vulvovaginal candidiasis.
Pathog Dis. 2017 Aug 31;75(6). doi: 10.1093/femspd/ftx061.
2
Molecular typing and in vitro fluconazole susceptibility of Candida species isolated from diabetic and nondiabetic women with vulvovaginal candidiasis in India.
J Microbiol Immunol Infect. 2011 Jun;44(3):166-71. doi: 10.1016/j.jmii.2011.01.020. Epub 2011 Jan 18.
3
Prevalence of vulvovaginal candidiasis among pregnant women in the Ho municipality, Ghana: species identification and antifungal susceptibility of Candida isolates.
BMC Pregnancy Childbirth. 2020 May 6;20(1):266. doi: 10.1186/s12884-020-02963-3.
4
Pattern of Candida species isolated from patients with diabetes mellitus and vulvovaginal candidiasis and their response to single dose oral fluconazole therapy.
J Infect. 2006 Feb;52(2):111-7. doi: 10.1016/j.jinf.2005.03.005.
5
Microsatellite analysis of Candida isolates from recurrent vulvovaginal candidiasis.
J Med Microbiol. 2012 Aug;61(Pt 8):1091-1096. doi: 10.1099/jmm.0.043992-0. Epub 2012 Apr 26.
6
Epidemiology and antifungal susceptibility patterns of Candida isolates from Greek women with vulvovaginal candidiasis.
Mycoses. 2019 Aug;62(8):692-697. doi: 10.1111/myc.12946. Epub 2019 Jun 12.
7
Biofilms Formed by Isolates from Recurrent Vulvovaginal Candidiasis Patients Are Heterogeneous and Insensitive to Fluconazole.
Antimicrob Agents Chemother. 2017 Aug 24;61(9). doi: 10.1128/AAC.01065-17. Print 2017 Sep.
8
The bacterial communities in vagina of different Candida species-associated vulvovaginal candidiasis.
Microb Pathog. 2023 Apr;177:106037. doi: 10.1016/j.micpath.2023.106037. Epub 2023 Feb 25.
9
Prevalence of Candida glabrata and its response to boric acid vaginal suppositories in comparison with oral fluconazole in patients with diabetes and vulvovaginal candidiasis.
Diabetes Care. 2007 Feb;30(2):312-7. doi: 10.2337/dc06-1469.
10
Prevalence of Candida albicans and non-albicans isolates from vaginal secretions: comparative evaluation of colonization, vaginal candidiasis and recurrent vaginal candidiasis in diabetic and non-diabetic women.
Sao Paulo Med J. 2014;132(2):116-20. doi: 10.1590/1516-3180.2014.1322640.
引用本文的文献
1
Drivers of diversification in fungal pathogen populations.
PLoS Pathog. 2024 Sep 12;20(9):e1012430. doi: 10.1371/journal.ppat.1012430. eCollection 2024 Sep.
2
Bacterial Vaginosis (BV) and Vaginal Microbiome Disorders in Women Suffering from Polycystic Ovary Syndrome (PCOS).
Diagnostics (Basel). 2024 Feb 12;14(4):404. doi: 10.3390/diagnostics14040404.
3
Oral Intake of the Commercial Probiotic Blend Synbio for the Management of Vaginal Dysbiosis.
J Clin Med. 2022 Dec 20;12(1):27. doi: 10.3390/jcm12010027.
4
A study on the accuracy of a new fluorescent detection method for vaginal fungi.
BMC Womens Health. 2022 Dec 30;22(1):559. doi: 10.1186/s12905-022-02151-9.
5
Vulvovaginal Candidosis (Excluding Mucocutaneous Candidosis): Guideline of the German (DGGG), Austrian (OEGGG) and Swiss (SGGG) Society of Gynecology and Obstetrics (S2k-Level, AWMF Registry Number 015/072, September 2020).
Geburtshilfe Frauenheilkd. 2021 Apr;81(4):398-421. doi: 10.1055/a-1345-8793. Epub 2021 Apr 14.
6
Guideline: Vulvovaginal candidosis (AWMF 015/072, level S2k).
Mycoses. 2021 Jun;64(6):583-602. doi: 10.1111/myc.13248. Epub 2021 Feb 27.
7
Pathogenesis and Clinical Relevance of Biofilms in Vulvovaginal Candidiasis.
Front Microbiol. 2020 Nov 11;11:544480. doi: 10.3389/fmicb.2020.544480. eCollection 2020.
8
Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health.
Microb Cell Fact. 2020 Nov 7;19(1):203. doi: 10.1186/s12934-020-01464-4.
9
Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review.
Ann Clin Microbiol Antimicrob. 2020 Jan 28;19(1):5. doi: 10.1186/s12941-020-0347-4.
本文引用的文献
1
An integrated genomic and transcriptomic survey of mucormycosis-causing fungi.
Nat Commun. 2016 Jul 22;7:12218. doi: 10.1038/ncomms12218.
2
The genome sequence of four isolates from the family Lichtheimiaceae.
Pathog Dis. 2015 Jul;73(5). doi: 10.1093/femspd/ftv024. Epub 2015 Apr 9.
3
Genetic and phenotypic intra-species variation in Candida albicans.
Genome Res. 2015 Mar;25(3):413-25. doi: 10.1101/gr.174623.114. Epub 2014 Dec 11.
4
RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.
Bioinformatics. 2014 May 1;30(9):1312-3. doi: 10.1093/bioinformatics/btu033. Epub 2014 Jan 21.
5
Daily temporal dynamics of vaginal microbiota before, during and after episodes of bacterial vaginosis.
Microbiome. 2013 Dec 2;1(1):29. doi: 10.1186/2049-2618-1-29.
6
Inferring evolutionary trees with PAUP*.
Curr Protoc Bioinformatics. 2003 Feb;Chapter 6:Unit 6.4. doi: 10.1002/0471250953.bi0604s00.
7
Using MUMmer to identify similar regions in large sequence sets.
Curr Protoc Bioinformatics. 2003 Feb;Chapter 10:Unit 10.3. doi: 10.1002/0471250953.bi1003s00.
8
Velvet: algorithms for de novo short read assembly using de Bruijn graphs.
Genome Res. 2008 May;18(5):821-9. doi: 10.1101/gr.074492.107. Epub 2008 Mar 18.
9
ALLPATHS: de novo assembly of whole-genome shotgun microreads.
Genome Res. 2008 May;18(5):810-20. doi: 10.1101/gr.7337908. Epub 2008 Mar 13.
10
Differential expression of Candida albicans secreted aspartyl proteinase in human vulvovaginal candidiasis.
Mycoses. 2007 Sep;50(5):383-90. doi: 10.1111/j.1439-0507.2007.01384.x.
Zotero 插件