细胞因子和长非编码 RNA
Cytokines and Long Noncoding RNAs.
机构信息
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064.
Program in Innate Immunity, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, Massachusetts 01655.
出版信息
Cold Spring Harb Perspect Biol. 2018 Jun 1;10(6):a028589. doi: 10.1101/cshperspect.a028589.
Cytokines and long noncoding RNAs (lncRNAs) are intertwined in the regulatory circuit controlling immunity. lncRNA expression levels are altered following cytokine stimulation in a cell-type-specific fashion. lncRNAs, in turn, regulate the inducible expression of cytokines following immune activation. These studies position lncRNAs as important regulators of gene expression within the complex pathways of the immune system. Our understanding of the functions of lncRNAs is just beginning. Current methodologies for functionally understanding how these transcripts mediate their effects are unable to keep up with the speed of genomic outputs cataloging thousands of these novel genes. In this review, we highlight the interplay between cytokines and lncRNAs and speculate on the future utility of these genes as potential biomarkers and therapeutic targets for the treatment of inflammatory disorders.
细胞因子和长非编码 RNA（lncRNA）交织在控制免疫的调节回路中。细胞因子刺激后，lncRNA 的表达水平会以细胞类型特异性的方式发生改变。反过来，lncRNA 调节免疫激活后细胞因子的诱导表达。这些研究将 lncRNA 定位为免疫系统复杂途径中基因表达的重要调节剂。我们对 lncRNA 功能的理解才刚刚开始。目前用于功能理解这些转录本如何介导其作用的方法学无法跟上基因组输出的速度，这些输出正在对数以千计的这些新基因进行编目。在这篇综述中，我们强调了细胞因子和 lncRNA 之间的相互作用，并推测这些基因作为炎症性疾病治疗的潜在生物标志物和治疗靶点的未来应用。
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