姑息治疗与1期试验：改善生活质量及提供教育的干预措施
Palliative Care and Phase 1 Trials: Intervention to Improve Quality of Life and Provide Education .
作者信息
Ferrell Betty R, Chung Vincent, Koczywas Marianna, Williams Anna Cathy, Gallagher Denise, Fischer Patricia, Smith Thomas J
机构信息
City of Hope Comprehensive Cancer Center.
Sidney Kimmel Comprehensive Cancer Center.
出版信息
Clin J Oncol Nurs. 2017 Aug 1;21(4):473-479. doi: 10.1188/17.CJON.473-479.
BACKGROUND: Patients in phase 1 clinical trials often have significant symptom burdens and quality-of-life concerns that increase as they progress along the cancer trajectory and experience drug toxicities from the clinical trial. .
OBJECTIVES: The interdisciplinary intervention described is aimed at providing optimum palliative care to support patients with solid tumors participating in a phase 1 clinical trial. .
METHODS: The intervention includes a baseline evaluation using quantitative surveys, a comprehensive palliative care assessment by a research nurse based on patient baseline evaluation, and a goals-of-care discussion by the treating oncologist. The second component includes an interdisciplinary meeting where palliative care recommendations are made, followed by two patient education sessions. .
FINDINGS
The initial experience with the palliative care intervention suggests a need for support for this population, as well as potential benefits from integrating palliative care for patients enrolled in phase 1 clinical trials.
背景
1期临床试验中的患者通常有显著的症状负担和生活质量问题，随着他们在癌症进程中推进并经历临床试验的药物毒性，这些问题会加剧。
目的
所描述的跨学科干预旨在提供最佳姑息治疗，以支持参与1期临床试验的实体瘤患者。
方法
该干预包括使用定量调查进行基线评估、研究护士根据患者基线评估进行的全面姑息治疗评估，以及主治肿瘤学家进行的治疗目标讨论。第二个组成部分包括一个提出姑息治疗建议的跨学科会议，随后是两次患者教育课程。
结果
姑息治疗干预的初步经验表明，这一人群需要支持，并且将姑息治疗纳入1期临床试验的患者可能会受益。
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