细胞-细胞连接的机械感知和转导。
Mechanosensing and Mechanotransduction at Cell-Cell Junctions.
机构信息
Institute for Molecular Bioscience, Division of Cell Biology and Molecular Medicine, The University of Queensland, St. Lucia, Brisbane 4072, Australia.
Mechanobiology Institute, National University of Singapore, Singapore 117411.
出版信息
Cold Spring Harb Perspect Biol. 2018 Aug 1;10(8):a028761. doi: 10.1101/cshperspect.a028761.
Cell adhesion systems are defined by their ability to resist detachment force. Our understanding of the biology of cell-cell adhesions has recently been transformed by the realization that many of the forces that act on those adhesions are generated by the cells that they couple together; and that force at adhesive junctions can be sensed to regulate cell behavior. Here, we consider the mechanisms responsible for applying force to cell-cell junctions and the mechanosensory pathways that detect those forces. We focus on cadherins, as these are the best-studied examples to date, but it is likely that similar principles will apply to other molecular systems that can engage with force-generators within cells and physically couple those cells together.
细胞黏附系统的定义特征是其抵抗脱落力的能力。最近，人们认识到，许多作用于这些黏附连接的力是由它们连接在一起的细胞产生的，而黏附连接处的力可以被感知以调节细胞行为，这一认识极大地改变了我们对细胞-细胞黏附生物学的理解。在这里，我们考虑将力施加到细胞-细胞连接的机制以及检测这些力的机械感受器通路。我们专注于钙黏蛋白，因为迄今为止这些是研究得最好的例子，但类似的原理可能适用于其他分子系统，这些系统可以与细胞内的力发生器相互作用，并将这些细胞物理连接在一起。
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