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一锅法经济与一锅法合成

Pot economy and one-pot synthesis.

作者信息

Hayashi Yujiro

机构信息

Department of Chemistry , Graduate School of Science , Tohoku University , 6-3 Aramaki-Aza Aoba, Aoba-ku , Sendai 980-8578 , Japan . Email:

出版信息

Chem Sci. 2016 Feb 1;7(2):866-880. doi: 10.1039/c5sc02913a. Epub 2016 Jan 6.

Abstract

The one-pot synthesis of a target molecule in the same reaction vessel is widely considered to be an efficient approach in synthetic organic chemistry. In this review, the characteristics and limitations of various one-pot syntheses of biologically active molecules are explained, primarily involving organocatalytic methods as key tactics. Besides catalysis, the pot-economy concepts presented herein are also applicable to organometallic and organic reaction methods in general.

摘要

在同一反应容器中一锅法合成目标分子被广泛认为是有机合成化学中的一种有效方法。在这篇综述中,解释了各种生物活性分子一锅法合成的特点和局限性,主要涉及以有机催化方法作为关键策略。除了催化作用外,本文提出的“一锅经济性”概念通常也适用于有机金属和有机反应方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8695/5529999/39cc627f7c38/c5sc02913a-s1.jpg

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