Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.
School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Psychiatry Clin Neurosci. 2018 Jan;72(1):28-34. doi: 10.1111/pcn.12605. Epub 2017 Oct 20.
Recovery, or functional remission, represents the ultimate treatment goal in schizophrenia. Despite its importance, a standardized definition of remission is still lacking, thus reported rates significantly vary across studies. Moreover, the effects of rehabilitative interventions on recovery have not been thoroughly investigated. This study aimed to evaluate recovery in a sample of patients with chronic schizophrenia engaged in rehabilitation programs and to explore contributing factors, with a focus on sociocognitive rehabilitative interventions.
Data from 104 patients with schizophrenia treated either with a standard rehabilitation program, including cognitive remediation (n = 46), or the latter plus a specific sociocognitive intervention (n = 58), and assessed for psychopathology, cognition, social cognition, and Quality of Life Scale, were retrospectively analyzed for this study.
Recovery, evaluated with the Quality of Life Scale, was achieved by 56.76% of patients in our sample. While no effects were observed for clinical, cognitive, or sociocognitive variables, participation in the sociocognitive rehabilitative interventions was positively associated with recovery.
Our results indicate that high rates of recovery can be achieved in patients treated with psychosocial interventions and suggest that rehabilitative programs targeting social cognition may further facilitate the process of recovery. If confirmed, these results may have relevant implications for daily clinical practice and service provision, allowing clinicians to develop and optimize specific rehabilitation programs in order to promote recovery.
恢复,或功能缓解,代表精神分裂症的最终治疗目标。尽管其重要性,但缓解的标准化定义仍缺乏,因此报告的缓解率在研究之间差异显著。此外,康复干预对恢复的影响尚未得到彻底研究。本研究旨在评估参与康复计划的慢性精神分裂症患者样本中的恢复情况,并探讨其影响因素,重点是社会认知康复干预。
本研究回顾性分析了 104 名接受标准康复计划(包括认知矫正治疗,n=46)或标准康复计划加特定社会认知干预(n=58)治疗的精神分裂症患者的数据,评估了他们的精神病理学、认知、社会认知和生活质量量表。
在我们的样本中,56.76%的患者达到了生活质量量表评估的缓解。虽然临床、认知或社会认知变量没有影响,但参与社会认知康复干预与恢复呈正相关。
我们的结果表明,接受心理社会干预治疗的患者可以达到较高的缓解率,并表明针对社会认知的康复计划可能进一步促进恢复过程。如果得到证实,这些结果可能对日常临床实践和服务提供具有重要意义,使临床医生能够制定和优化特定的康复计划,以促进恢复。