长链非编码 RNA 在风湿性疾病中的作用。
The role of long non-coding RNAs in rheumatic diseases.
机构信息
Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 145 Shan Dong Road (c), Shanghai 200001, China.
Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences (SIBS), University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), 320 Yueyang Road, Shanghai, China.
出版信息
Nat Rev Rheumatol. 2017 Nov;13(11):657-669. doi: 10.1038/nrrheum.2017.162. Epub 2017 Oct 5.
Long non-coding RNAs (lncRNAs) have emerged as key epigenetic regulators that govern gene expression and influence multiple biological processes. Accumulating evidence demonstrates that lncRNAs have critical roles in immune cell development and function. In this Review, the molecular mechanisms of gene expression regulation by lncRNAs are described and current knowledge of the role of lncRNAs in immune regulation and inflammation are presented, highlighting strategies for defining the roles of lncRNAs in the pathogenesis of multiple rheumatic diseases. Finally, research progress in understanding the role of lncRNAs in rheumatic diseases is discussed.
长非编码 RNA（lncRNA）已成为关键的表观遗传调控因子，可调控基因表达并影响多种生物学过程。越来越多的证据表明，lncRNA 在免疫细胞的发育和功能中发挥着关键作用。在这篇综述中，描述了 lncRNA 调控基因表达的分子机制，并介绍了 lncRNA 在免疫调节和炎症中的作用的现有知识，重点介绍了确定 lncRNA 在多种风湿性疾病发病机制中的作用的策略。最后，讨论了在理解 lncRNA 在风湿性疾病中的作用方面的研究进展。
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