Brenner Lisa A, Forster Jeri E, Hoffberg Adam S, Matarazzo Bridget B, Hostetter Trisha A, Signoracci Gina, Simpson Grahame K
VA Rocky Mountain Mental Illness Research, Education and Clinical Center, Denver, Colorado (Drs Brenner, Forster, Matarazzo, and Signoracci, Mr Hoffberg, and Ms Hostetter); Department of Physical Medicine and Rehabilitation (Drs Brenner, Forster, and Signoracci), Department of Psychiatry (Drs Brenner, Matarazzo, and Signoracci), and Department of Neurology (Dr Brenner), University of Colorado Anschutz Medical Campus, Aurora, Colorado; and Brain Injury Rehabilitation Research Group, Ingham Institute of Applied Medical Research, and John Walsh Centre for Rehabilitation Research, Kolling Institute, University of Sydney New South Wales, Australia (Dr Simpson).
J Head Trauma Rehabil. 2018 Mar/Apr;33(2):E64-E73. doi: 10.1097/HTR.0000000000000351.
To evaluate the efficacy of a psychological intervention to reduce moderate to severe hopelessness among Veterans with moderate to severe traumatic brain injury (TBI).
Two-arm parallel group, controlled, randomized crossover trial, with 3-month follow-up for those initially allocated to treatment. Participants were randomly allocated in blocks of 4 on a 1:1 ratio to treatment (n = 15) or waitlist (n = 20) groups.
A Veterans Affairs Medical Center.
Veterans between the ages of 26 and 65 years, with a history of moderate to severe TBI, and moderate to severe hopelessness.
A 20-hour manualized small group cognitive-behavioral intervention.
Beck Hopelessness Scale (primary), Beck Depression Inventory, and Beck Scale for Suicide Ideation.
A significant difference between groups was found for postintervention scores on the Beck Hopelessness Scale (P = .03). Significant decreases were maintained at follow-up. For those initially allocated to the waitlist group who completed the intervention, treatment gains were noted in decreased hopelessness (P = .01) and depression (P = .003).
Findings from this trial provide additional support for the efficacy of this method of psychological treatment of hopelessness among individuals with moderate to severe TBI.
评估一种心理干预措施对中重度创伤性脑损伤(TBI)退伍军人中重度绝望情绪的疗效。
双臂平行组对照随机交叉试验,对最初分配接受治疗的患者进行3个月随访。参与者按1:1比例以4人一组的方式随机分配至治疗组(n = 15)或候补组(n = 20)。
一家退伍军人事务医疗中心。
年龄在26至65岁之间,有中重度TBI病史且存在中重度绝望情绪的退伍军人。
一项为期20小时的手册化小组认知行为干预。
贝克绝望量表(主要指标)、贝克抑郁量表和贝克自杀意念量表。
干预后贝克绝望量表得分在两组间存在显著差异(P = .03)。随访时显著降低的情况得以维持。对于最初分配至候补组且完成干预的患者,在绝望情绪降低(P = .01)和抑郁程度降低(P = .003)方面均观察到治疗效果。
该试验结果为这种心理治疗方法对中重度TBI患者绝望情绪的疗效提供了更多支持。