白藜芦醇诱导的表观遗传调控机制。
Epigenetic Regulatory Mechanisms Induced by Resveratrol.
机构信息
School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800903 Araraquara, Brazil.
Institute of Chemistry, São Paulo State University (UNESP), 14800060 Araraquara, Brazil.
出版信息
Nutrients. 2017 Nov 1;9(11):1201. doi: 10.3390/nu9111201.
Abstract
Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1).
摘要
白藜芦醇（RVT）是世界范围内研究最多的天然化合物之一，因为它具有治疗多种疾病的潜在用途，包括癌症、糖尿病、心血管疾病、神经退行性疾病和代谢紊乱。然而，RVT 在所有这些情况下的作用机制尚不完全清楚，因为它不仅可以改变生化途径，还可以改变表观遗传机制。在本文中，我们分析了 RVT 表现出的生物学活性，重点是表观遗传机制，特别是与 DNA 甲基转移酶（DNMT）、组蛋白去乙酰化酶（HDAC）和赖氨酸特异性去甲基化酶-1（LSD1）相关的机制。
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