Villa Alessandro, Akintoye Sunday O
Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA; Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, 1620 Tremont Street, Suite BC3-028, Boston, MA 02118, USA.
Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, Robert Schattner Room 211, 240 South 40th Street, Philadelphia, PA 19104, USA.
Dent Clin North Am. 2018 Jan;62(1):131-142. doi: 10.1016/j.cden.2017.08.010. Epub 2017 Oct 12.
Oral cancer therapies are associated with orofacial complications that could result in dose-limiting cancer treatment and consequent suboptimal tumor control. Oral cancer treatment complications include oral mucositis, salivary gland hypofunction, odontogenic infections, pain, dermatitis, neurotoxicity, soft tissue fibrosis, trismus, osteoradionecrosis, and potential cancer recurrence. These complications significantly affect cancer survivorship, quality of life, and psychosocial status. Effective dental management of patients with oral cancer involves the coordination of care among several health care professionals before, during, and after cancer therapy. The goal is to minimize complications, and establish optimal quality of life for survivors.
口腔癌治疗会引发口面部并发症,这些并发症可能导致癌症治疗剂量受限,进而影响肿瘤控制效果。口腔癌治疗并发症包括口腔黏膜炎、唾液腺功能减退、牙源性感染、疼痛、皮炎、神经毒性、软组织纤维化、牙关紧闭、放射性骨坏死以及潜在的癌症复发。这些并发症会显著影响癌症患者的生存率、生活质量和心理社会状况。对口腔癌患者进行有效的牙科管理,需要在癌症治疗前、治疗期间和治疗后,由多名医疗保健专业人员协调护理工作。目标是尽量减少并发症,为幸存者建立最佳生活质量。