不安腿综合征与高血压的关联：基于九项人群研究的荟萃分析。
Association between restless legs syndrome and hypertension: a meta-analysis of nine population-based studies.
机构信息
Department of Neurology, The Affiliated Hospital of Jiujiang University, No. 57, Xunyang East Road, Xunyang District, Jiujiang, 332000, China.
Department of Hematology, The Second Affiliated Hospital, Xi'an Jiaotong University, The West Five Road, No. 157, Xi'an, Shanxi Province, 710004, China.
出版信息
Neurol Sci. 2018 Feb;39(2):235-242. doi: 10.1007/s10072-017-3182-4. Epub 2017 Nov 13.
Previous population-based studies evaluating the association between restless legs syndrome (RLS) and cardiovascular risk factors have showed inconsistent results, especially for the relationship between RLS and hypertension. We, therefore, aimed to meta-analyze to assess the association between RLS and hypertension. PubMed and Embase databases were systematically searched to identify eligible studies. Nine population-based cross-sectional studies were selected for inclusion, involving 102,408 individuals. Overall, the prevalence of hypertension in RLS subjects was higher than those without RLS (OR = 1.36, 95% CI, 1.18-1.57, P = 0.043). Our findings indicate that RLS is associated with increased blood pressure. More large-scale and prospective studies are warranted to further clarify the relationship and its potential mechanism.
先前基于人群的研究评估了不宁腿综合征（RLS）与心血管危险因素之间的关系，但结果不一致，尤其是 RLS 与高血压之间的关系。因此，我们旨在进行荟萃分析以评估 RLS 与高血压之间的关系。系统地检索了 PubMed 和 Embase 数据库以确定符合条件的研究。选择了 9 项基于人群的横断面研究，共涉及 102408 人。总体而言，RLS 患者的高血压患病率高于无 RLS 患者（OR=1.36，95%CI，1.18-1.57，P=0.043）。我们的研究结果表明，RLS 与血压升高有关。需要更多的大规模前瞻性研究来进一步阐明这种关系及其潜在机制。
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