酰胺在钌（II）催化的 C-H 活化过程中的远端弱配位。
Distal Weak Coordination of Acetamides in Ruthenium(II)-Catalyzed C-H Activation Processes.
机构信息
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Göttingen, Germany.
出版信息
Angew Chem Int Ed Engl. 2018 Jan 15;57(3):765-768. doi: 10.1002/anie.201711108. Epub 2017 Dec 12.
PMID:29141119
Abstract
C-H activations with challenging arylacetamides were accomplished by versatile ruthenium(II) biscarboxylate catalysis. The distal C-H functionalization offers ample scope-including twofold oxidative C-H functionalizations and alkyne hydroarylations-through facile base-assisted internal electrophilic-type substitution (BIES) C-H ruthenation by weak O-coordination.
摘要
通过多功能钌（II）双羧酸催化实现了具有挑战性的芳基乙酰胺的 C-H 活化。通过易于碱辅助的内部亲电型取代（BIES）C-H 钌化作用，通过弱 O-配位实现了远程 C-H 功能化，为包括两倍氧化 C-H 功能化和炔烃氢芳基化在内的多种功能提供了广阔的范围。
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