脑成熟——胎儿和儿童大脑生化组成的差异
Brain Maturation-Differences in Biochemical Composition of Fetal and Child's Brain.
作者信息
Urbanik Andrzej, Cichocka Monika, Kozub Justyna, Karcz Paulina, Herman-Sucharska Izabela
机构信息
a Department of Radiology , Uniwersytet Jagiellonski w Krakowie Collegium Medicum , Krakow , Poland.
b Department of Electroradiology , Uniwersytet Jagiellonski w Krakowie Collegium Medicum , Krakow , Poland.
出版信息
Fetal Pediatr Pathol. 2017 Oct;36(5):380-386. doi: 10.1080/15513815.2017.1346019.
INTRODUCTION
The aim of this study was to evaluate differences in H MRS spectra of the brain of fetuses and children from 6 to 11 years of age.
MATERIAL AND METHODS
21 healthy fetuses in the third trimester and 22 children were examined using the proton nuclear magnetic resonance. The relative metabolite concentrations to the sum of all metabolites were calculated.
RESULTS
In the H MRS spectra of the brain from fetuses and children, there are the same characteristic peaks: N-acetylaspartate (NAA), creatine (Cr), choline (Cho), and myo-inositol (mI). NAA/Σ, NAA/Cr, and Cr/Σ concentrations are significantly higher and Cho/Σ, Cho/Cr, mI/Σ, and mI/Cr are significantly lower in children than in the fetuses.
CONCLUSIONS
It was found that the brain metabolism changes from fetal life to childhood. The results of this study may provide a valuable basis for further research on brain maturation and "healthy aging."
引言
本研究的目的是评估胎儿及6至11岁儿童大脑的氢磁共振波谱（H MRS）差异。
材料与方法
使用质子核磁共振对21例孕晚期健康胎儿和22名儿童进行检查。计算各代谢物浓度相对于所有代谢物总和的相对值。
结果
胎儿和儿童大脑的H MRS波谱中存在相同的特征峰：N-乙酰天门冬氨酸（NAA）、肌酸（Cr）、胆碱（Cho）和肌醇（mI）。儿童的NAA/Σ、NAA/Cr和Cr/Σ浓度显著高于胎儿，而Cho/Σ、Cho/Cr、mI/Σ和mI/Cr则显著低于胎儿。
结论
发现大脑代谢从胎儿期到儿童期会发生变化。本研究结果可能为进一步研究大脑成熟和“健康衰老”提供有价值的基础。
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