深入了解上下文 TGF-β 信号转导的机制。
Mechanistic insight into contextual TGF-β signaling.
机构信息
Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States.
出版信息
Curr Opin Cell Biol. 2018 Apr;51:1-7. doi: 10.1016/j.ceb.2017.10.001. Epub 2017 Nov 14.
Abstract
Transforming growth factor-β (TGF-β) controls a wide range of cellular functions by activating both SMADs and non-SMAD pathways. In different tissue or physiological environment, cellular responses to TGF-β can be diverse, even opposite. Complex regulations at the level of ligand mobilization, receptor presentation, and the network of intracellular signal transducers afford the TGF-β pathway with versatile means to induce precise cellular responses in accordance to specific contextual demands. This article summarizes recent development in how cells manage their responses to TGF-β through ligand activation, receptor abundance, as well as SMAD-dependent and SMAD-independent mechanisms.
摘要
转化生长因子-β（TGF-β）通过激活 SMAD 和非 SMAD 途径来控制广泛的细胞功能。在不同的组织或生理环境中，细胞对 TGF-β 的反应可能是多样的，甚至是相反的。在配体动员、受体表达和细胞内信号转导网络的水平上的复杂调节为 TGF-β 途径提供了多种手段，根据特定的上下文需求诱导精确的细胞反应。本文总结了细胞如何通过配体激活、受体丰度以及依赖 SMAD 和非依赖 SMAD 的机制来管理其对 TGF-β 的反应的最新进展。
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