用于细胞内递送的刺激响应性纳米载体。
Stimuli-responsive nanocarriers for intracellular delivery.
作者信息
Tayo Lemmuel L
机构信息
School of Chemical, Biological, and Materials Engineering and Sciences, Mapúa University, Muralla Street, 1002, Intramuros Manila, Philippines.
出版信息
Biophys Rev. 2017 Dec;9(6):931-940. doi: 10.1007/s12551-017-0341-z. Epub 2017 Nov 25.
Abstract
The emergence of different nanoparticles (NPs) has made a significant revolution in the field of medicine. Different NPs in the form of metallic NPs, dendrimers, polymeric NPs, carbon quantum dots and liposomes have been functionalized and used as platforms for intracellular delivery of biomolecules, drugs, imaging agents and nucleic acids. These NPs are designed to improve the pharmacokinetic properties of the drug, improve their bioavailability and successfully surpass physiological or pathological obstacles in the biological system so that therapeutic efficacy is achieved. In this review I present some of the current approaches used in intracellular delivery systems, with a focus on various stimuli-responsive nanocarriers, including cell-penetrating peptides, to highlight their various biomedical applications.
摘要
不同纳米颗粒（NPs）的出现给医学领域带来了重大变革。金属纳米颗粒、树枝状大分子、聚合物纳米颗粒、碳量子点和脂质体等不同形式的纳米颗粒已被功能化，并用作生物分子、药物、成像剂和核酸细胞内递送的平台。这些纳米颗粒旨在改善药物的药代动力学性质，提高其生物利用度，并成功跨越生物系统中的生理或病理障碍，从而实现治疗效果。在本综述中，我介绍了一些细胞内递送系统中目前使用的方法，重点关注各种刺激响应性纳米载体，包括细胞穿透肽，以突出它们的各种生物医学应用。
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Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:698-707. doi: 10.1016/j.msec.2017.02.017. Epub 2017 Feb 7.
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