miR-195-5p 通过靶向 TRIM14 抑制口腔鳞状细胞癌的增殖、迁移和侵袭。
miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14.
机构信息
Medical College, Nankai University, Tianjin 300070, China.
Department of Oral and Maxillofacial Surgery, Chinese PLA General Hospital, Beijing 100853, China.
出版信息
Biomed Res Int. 2017;2017:7378148. doi: 10.1155/2017/7378148. Epub 2017 Oct 24.
MicroRNAs (miRNAs) play an essential role in tumor biological processes through interacting with specific gene targets. The involvement of miR-195-5p in cell proliferation, invasion, and migration has been demonstrated in several cancer cell lines, while its function in oral squamous cell carcinoma (OSCC) remains unclear. Here we find that miR-195-5p expression is lower in OSCC than in nontumor tissues, while its overexpression in cell lines can lead to the promotion of apoptosis and the reduction of cell growth, migration, and invasion. Moreover, we identify the tripartite motif-containing protein (TRIM14) as a target of miR-195-5p. Therefore, we reason that the tumor suppressor role of miR-195-5p in OSCC is dependent on the interaction with TRIM14.
微小 RNA（miRNAs）通过与特定基因靶标相互作用，在肿瘤生物学过程中发挥着重要作用。miR-195-5p 在几种癌细胞系中的增殖、侵袭和迁移中发挥作用，但其在口腔鳞状细胞癌（OSCC）中的功能尚不清楚。在这里，我们发现 miR-195-5p 在 OSCC 中的表达低于非肿瘤组织，而其在细胞系中的过表达可导致细胞凋亡的促进和细胞生长、迁移和侵袭的减少。此外，我们确定了三肽基含肽（TRIM14）是 miR-195-5p 的靶标。因此，我们认为 miR-195-5p 在 OSCC 中的肿瘤抑制作用依赖于与 TRIM14 的相互作用。
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