囊性纤维化患儿一年内每月氮多次呼吸冲洗的可变性。
Variability of monthly nitrogen multiple-breath washout during one year in children with cystic fibrosis.
机构信息
CF-Centre Copenhagen, Paediatric Pulmonary Service, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; Research Unit on Women's and Children's Health, Copenhagen University Hospital, Rigshospitalet, Tagensvej 20, DK-2100 Copenhagen, Denmark.
CF-Centre Copenhagen, Paediatric Pulmonary Service, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; Research Unit on Women's and Children's Health, Copenhagen University Hospital, Rigshospitalet, Tagensvej 20, DK-2100 Copenhagen, Denmark.
出版信息
J Cyst Fibros. 2018 Mar;17(2):242-248. doi: 10.1016/j.jcf.2017.11.007. Epub 2017 Dec 19.
BACKGROUND
Knowledge of between-session variability of nitrogen multiple-breath washout (NMBW) indices is crucial when designing longitudinal interventional studies and in disease monitoring using NMBW as end-point. Such information is currently sparse.
METHODS
Monthly triplets of NMBW were prospectively obtained from 14 children with CF during one year. Linear mixed models were used to analyze variability. Our aim was to assess between-session variability of NMBW indices from repeated measurements and compare LCI derived from different software packages currently in use (TestPoint® vs. Spiroware®).
RESULTS
Baseline LCI (median; range) was 9.37 (6.82; 12.08). Between-session differences in LCI measurements were up to 25%. Intra Class Correlation-Coefficient was 0.82. There was no systematic difference between LCI measurements derived from the two software packages (p=0.18); however, variability was significantly higher using Spiroware®.
CONCLUSIONS
We report between-session variability of LCI using NMBW in school-age children and adolescents with CF. LCI changes exceeding 25% may be considered clinically relevant. TestPoint® and Spiroware® can be used interchangeably in longitudinal studies.
背景
在设计纵向干预研究和使用 NMBW 作为终点进行疾病监测时，了解氮多次呼吸冲洗（NMBW）指数的会话间变异性至关重要。目前此类信息较为缺乏。
方法
在一年的时间里，前瞻性地从 14 名 CF 儿童中获得每月三组 NMBW。使用线性混合模型进行分析。我们的目的是评估重复测量中 NMBW 指数的会话间变异性，并比较当前使用的不同软件包（TestPoint®与 Spiroware®）得出的 LCI。
结果
基线 LCI（中位数；范围）为 9.37（6.82；12.08）。LCI 测量的会话间差异高达 25%。组内相关系数为 0.82。两种软件包得出的 LCI 测量值之间没有系统差异（p=0.18）；然而，Spiroware®的变异性显著更高。
结论
我们报告了使用 NMBW 测量 CF 学龄儿童和青少年的 LCI 会话间变异性。LCI 变化超过 25%可能被认为具有临床意义。TestPoint®和 Spiroware®可在纵向研究中互换使用。
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