基于活性的生物体系铁离子荧光探针
Activity-based sensing fluorescent probes for iron in biological systems.
机构信息
Department of Chemistry, University of California, Berkeley, CA 94720, USA.
Department of Chemistry, University of California, Berkeley, CA 94720, USA; Departments of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
出版信息
Curr Opin Chem Biol. 2018 Apr;43:113-118. doi: 10.1016/j.cbpa.2017.12.010. Epub 2018 Jan 5.
Abstract
Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a potentially dangerous toxin that can trigger oxidative stress and damage. New methods that enable monitoring of iron in living biological systems, particularly in labile Fe forms, can help identify its contributions to physiology, aging, and disease. In this review, we summarize recent developments in activity-based sensing (ABS) probes for fluorescence Fe detection.
摘要
铁是生命必需的营养物质，其在不同氧化态之间循环的能力对于从氧运输和呼吸到核苷酸合成和表观遗传调控等过程都是必需的。然而，这种相同的氧化还原能力也使铁，如果没有得到适当的调节，成为一种潜在的危险毒素，可引发氧化应激和损伤。新的方法可以帮助监测活的生物系统中的铁，特别是在不稳定的 Fe 形式中，这可以帮助确定铁对生理、衰老和疾病的贡献。在这篇综述中，我们总结了用于荧光 Fe 检测的基于活性的传感（ABS）探针的最新进展。
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