SURMetaGIT研究中，2型糖尿病肥胖女性接受Roux-en-Y胃旁路手术后，其旷置胃中胃饥饿素基因表达上调。
Upregulation of Ghrelin Gene Expression in the Excluded Stomach of Obese Women with Type 2 Diabetes After Roux-en-Y Gastric Bypass in the SURMetaGIT Study.
作者信息
Fonseca Danielle Cristina, Sala Priscila, Singer Joelle, Singer Pierre, Torrinhas Raquel Susana, Waitzberg Dan Linetzky
机构信息
Departamento de Gastroenterologia, Laboratório Metanutri (LIM 35), Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
出版信息
Obes Surg. 2018 Mar;28(3):877-880. doi: 10.1007/s11695-017-3098-3.
BACKGROUND
Mechanisms of type 2 diabetes remission (T2Dr) after Roux-en-Y gastric bypass (RYGB) in obese patients appear to involve gastrointestinal hormones.
OBJECTIVE
The objective of this study is to explore changes in ghrelin plasma levels and ghrelin gastrointestinal gene expression (GHRL) after RYGB, and their relationships to T2Dr.
SETTING
In 20 obese women with T2D, before and 3 months after RYGB, we assessed GHRL expression by microarray and quantitative RT-PCR in gastrointestinal biopsy samples and plasma levels of ghrelin.
RESULTS
After RYGB, GHRL expression increased in the excluded stomach (p < 0.05) with no change in other gastrointestinal sites. There were no significant changes in ghrelin plasma levels and no correlations with T2Dr.
CONCLUSIONS
After RYGB, over-expression of GHRL gene occurs only in the excluded stomach with no correlation to T2Dr.
背景
肥胖患者接受胃旁路手术（RYGB）后2型糖尿病缓解（T2Dr）的机制似乎涉及胃肠激素。
目的
本研究旨在探讨RYGB术后胃饥饿素血浆水平和胃饥饿素胃肠基因表达（GHRL）的变化及其与T2Dr的关系。
设置
在20例患有2型糖尿病的肥胖女性中，于RYGB术前及术后3个月，我们通过微阵列和定量逆转录聚合酶链反应评估胃肠活检样本中GHRL的表达以及胃饥饿素的血浆水平。
结果
RYGB术后，被旷置的胃中GHRL表达增加（p < 0.05），而其他胃肠部位无变化。胃饥饿素血浆水平无显著变化，且与T2Dr无相关性。
结论
RYGB术后，GHRL基因仅在被旷置的胃中过度表达，与T2Dr无关。
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