Kim Peterson, Johanna Anderson, Erin Boundy, Lauren Ferguson, Ellen McCleery, Kallie Waldrip, are with the Department of Veterans Affairs, VA Portland Health Care System, Evidence-Based Synthesis Program Coordinating Center, Portland, OR.
Am J Public Health. 2018 Mar;108(3):e1-e11. doi: 10.2105/AJPH.2017.304246.
Continued racial/ethnic health disparities were recently described as "the most serious and shameful health care issue of our time." Although the 2014 US Affordable Care Act-mandated national insurance coverage expansion has led to significant improvements in health care coverage and access, its effects on life expectancy are not yet known. The Veterans Health Administration (VHA), the largest US integrated health care system, has a sustained commitment to health equity that addresses all 3 stages of health disparities research: detection, understanding determinants, and reduction or elimination. Despite this, racial disparities still exist in the VHA across a wide range of clinical areas and service types.
To inform the health equity research agenda, we synthesized evidence on racial/ethnic mortality disparities in the VHA.
Our research librarian searched MEDLINE and Cochrane Central Registry of Controlled Trials from October 2006 through February 2017 using terms for racial groups and disparities.
We included studies if they compared mortality between any racial/ethnic minority and nonminority veteran groups or between different minority groups in the VHA (PROSPERO# CRD42015015974). We made study selection decisions on the basis of prespecified eligibility criteria. They were first made by 1 reviewer and checked by a second and disagreements were resolved by consensus (sequential review).
Two reviewers sequentially abstracted data on prespecified population, outcome, setting, and study design characteristics. Two reviewers sequentially graded the strength of evidence using prespecified criteria on the basis of 5 key domains: study limitations (study design and internal validity), consistency, directness, precision of the evidence, and reporting biases. We synthesized the evidence qualitatively by grouping studies first by racial/ethnic minority group and then by clinical area. For areas with multiple studies in the same population and outcome, we pooled their reported hazard ratios (HRs) using random effects models (StatsDirect version 2.8.0; StatsDirect Ltd., Altrincham, England). We created an evidence map using a bubble plot format to represent the evidence base in 5 dimensions: odds ratio or HR of mortality for racial/ethnic minority group versus Whites, clinical area, strength of evidence, statistical significance, and racial group.
From 2840 citations, we included 25 studies. Studies were large (n ≥ 10 000) and involved nationally representative cohorts, and the majority were of fair quality. Most studies compared mortality between Black and White veterans and found similar or lower mortality for Black veterans. However, we found modest mortality disparities (HR or OR = 1.07, 1.52) for Black veterans with stage 4 chronic kidney disease, colon cancer, diabetes, HIV, rectal cancer, or stroke; for American Indian and Alaska Native veterans undergoing noncardiac major surgery; and for Hispanic veterans with HIV or traumatic brain injury (most low strength).
AUTHOR'S CONCLUSIONS: Although the VHA's equal access health care system has reduced many racial/ethnic mortality disparities present in the private sector, our review identified mortality disparities that have persisted mainly for Black veterans in several clinical areas. However, because most mortality disparities were supported by single studies with imprecise findings, we could not draw strong conclusions about this evidence. More disparities research is needed for American Indian and Alaska Native, Asian, and Hispanic veterans overall and for more of the largest life expectancy gaps. Public Health Implications. Because of the relatively high prevalence of diabetes in Black veterans, further research to better understand and reduce this mortality disparity may be prioritized as having the greatest potential impact. However, other mortality disparities affect thousands of veterans and cannot be ignored.
最近有人指出,持续存在的种族/民族健康差异是“我们这个时代最严重、最可耻的医疗保健问题”。尽管 2014 年美国平价医疗法案(Affordable Care Act)要求实施的国家保险范围扩大,显著改善了医疗保健的覆盖范围和可及性,但它对预期寿命的影响尚不清楚。退伍军人健康管理局(Veterans Health Administration,VHA)是美国最大的综合性医疗保健系统,它一直致力于实现健康公平,涵盖了健康差异研究的所有三个阶段:发现、理解决定因素以及减少或消除。尽管如此,在广泛的临床领域和服务类型中,VHA 仍然存在种族差异。
为了制定健康公平研究议程,我们综合了 VHA 中种族/民族死亡率差异的证据。
我们的研究图书馆员使用种族群体和差异的术语,从 2006 年 10 月至 2017 年 2 月在 MEDLINE 和 Cochrane 对照试验中心注册处进行了搜索。
如果研究比较了任何少数民族和非少数民族退伍军人群体之间的死亡率,或者 VHA 内不同少数民族群体之间的死亡率,我们就将其纳入研究。我们根据预先规定的合格标准做出研究选择决定。这些标准由一名评审员首先做出,并由第二名评审员进行检查,如果存在分歧,则通过协商解决(顺序审查)。
两名评审员依次根据预先规定的人群、结局、环境和研究设计特征来提取数据。两名评审员根据五个关键领域的预先规定标准,依次对证据的强度进行分级:研究局限性(研究设计和内部有效性)、一致性、直接性、证据的精确性和报告偏倚。我们首先根据种族/少数民族群体对证据进行分组,然后根据临床领域对证据进行分组,对证据进行定性综合。对于同一人群和结局有多项研究的领域,我们使用随机效应模型对其报告的危险比(HR)进行了汇总(StatsDirect 版本 2.8.0;StatsDirect Ltd.,英国阿尔特林厄姆)。我们使用气泡图格式创建了一个证据图,以代表五个维度的证据基础:少数民族群体与白人相比的死亡率的比值比或 HR、临床领域、证据强度、统计学意义和种族群体。
从 2840 条引文,我们纳入了 25 项研究。这些研究规模较大(n≥10000),涉及全国代表性队列,其中大多数研究质量较高。大多数研究比较了黑人和白人退伍军人之间的死亡率,发现黑人士兵的死亡率相似或较低。然而,我们发现黑人士兵患有慢性肾脏病 4 期、结肠癌、糖尿病、艾滋病毒、直肠癌或中风;非心脏大手术的美洲印第安人和阿拉斯加原住民退伍军人;以及患有艾滋病毒或创伤性脑损伤的西班牙裔退伍军人,存在适度的死亡率差异(HR 或 OR=1.07,1.52)(大多数证据质量较低)。
尽管 VHA 的平等获得医疗保健系统减少了私营部门中许多种族/民族的死亡率差异,但我们的审查发现,在几个临床领域,黑人士兵的死亡率差异仍然存在。然而,由于大多数死亡率差异仅得到单一研究的支持,且研究结果不精确,因此我们无法对该证据得出强有力的结论。需要对美洲印第安人和阿拉斯加原住民、亚洲和西班牙裔退伍军人进行更多的差异研究,也需要对最大预期寿命差距进行更多的研究。公共卫生意义。由于黑人士兵的糖尿病患病率相对较高,因此可能需要进一步研究,以更好地了解和减少这一死亡率差异,因为这可能产生最大的影响。然而,其他死亡率差异也影响着数千名退伍军人,不容忽视。