宫颈阴道微生物群与生殖健康：简约的美德。

Cervicovaginal Microbiota and Reproductive Health: The Virtue of Simplicity.

机构信息

Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Cambridge, MA 02139, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Cambridge, MA 02139, USA; Harvard Medical School, Boston, MA 02115, USA.

出版信息

Cell Host Microbe. 2018 Feb 14;23(2):159-168. doi: 10.1016/j.chom.2018.01.013.

DOI:10.1016/j.chom.2018.01.013

PMID:29447695

Abstract

Cervicovaginal microbiota play a critical role in women's health and reproductive outcomes. Despite being one of the simplest commensal bacterial communities in the human body, we are only beginning to appreciate its complex dynamic nature and important role in host immune modulation. In this review, we discuss the "optimal" cervicovaginal bacterial community composition, the impact of microbiota on gynecologic and obstetric outcomes, and the hurdles to developing a deeper mechanistic understanding of the function of the cervicovaginal microbiome. We then describe efforts to durably alter microbial composition in this compartment by promotion of Lactobacillus colonization with probiotics, modulation of vaginal pH, hormonal administration, and the eradication of pathogenic bacteria with antibiotics. Finally, we draw on lessons learned from the deeply investigated gut microbiome to suggest future avenues of research into host-pathogen interactions in the female genital tract.

摘要

宫颈阴道微生物群在女性健康和生殖结果中起着关键作用。尽管它是人体中最简单的共生细菌群落之一，但我们才刚刚开始了解其复杂的动态性质及其在宿主免疫调节中的重要作用。在这篇综述中，我们讨论了“最佳”的宫颈阴道细菌群落组成、微生物群对妇科和产科结果的影响，以及在深入了解宫颈阴道微生物组功能方面面临的障碍。然后，我们描述了通过促进益生菌定殖以增加乳酸杆菌、调节阴道 pH 值、激素给药以及用抗生素根除病原菌来持久改变该部位微生物组成的努力。最后，我们借鉴从深入研究的肠道微生物组中获得的经验教训，提出未来研究女性生殖道中宿主-病原体相互作用的途径。