2 型糖尿病与非糖尿病患者伴与不伴种植体周围炎的临床及影像学种植体周围参数与全唾液白细胞介素-1β和白细胞介素-6 水平。
Clinical and Radiographic Peri-Implant Parameters and Whole Salivary Interleukin-1β and Interleukin-6 Levels among Type-2 Diabetic and Nondiabetic Patients with and without Peri-Implantitis.
机构信息
Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
出版信息
Med Princ Pract. 2018;27(2):133-138. doi: 10.1159/000488032. Epub 2018 Feb 28.
OBJECTIVE
The aim was to assess the peri-implant clinical and radiographic parameters and whole salivary levels of interleukin (IL)-1β and IL-6 among type 2 diabetic and nondiabetic patients with and without peri-implantitis.
MATERIAL AND METHODS
Ninety-one implants were placed in patients without type 2 diabetes mellitus (39 patients with and 52 patients without peri-implantitis; group 1). Eighty implants were placed in patients with diabetes (35 patients with and 45 patients without peri-implantitis; group 2). Peri-implant plaque index, bleeding on probing, probing depth, and marginal bone loss were measured. Unstimulated whole saliva samples were collected and IL-1β and IL-6 levels were measured using standard techniques. p < 0.05 was considered statistically significant.
RESULTS
In group 1, plaque index (p < 0.001), bleeding on probing (p < 0.001), probing depth (p < 0.001), and whole salivary IL-1β (p < 0.001) and IL-6 (p < 0.001) levels were significantly higher in patients with peri-implantitis than in those without peri-implantitis. Plaque index, bleeding on probing, probing depth, and marginal bone loss were comparable among all of the patients in group 2. Among patients with peri-implantitis, plaque index (p < 0.001), bleeding on probing (p < 0.001), probing depth (p < 0.001), marginal bone loss (p < 0.001), and whole salivary IL-1β (p < 0.001) and IL-6 (p < 0.001) levels were significantly higher in those with diabetes than in those without diabetes.
CONCLUSION
Among individuals without diabetes, peri-implant plaque index, bleeding on probing, probing depth, marginal bone loss, and whole salivary IL-1 β and IL-6 levels were higher among patients with peri-implantitis compared to patients without peri-implantitis. Among patients with diabetes, the severity of the measured parameters appears to be influenced by the glycemic status rather than by peri-implantitis.
目的
评估 2 型糖尿病患者和非糖尿病患者中伴或不伴种植体周围炎的种植体周围临床和影像学参数以及白细胞介素（IL）-1β和 IL-6 的全唾液水平。
材料和方法
91 个种植体植入无 2 型糖尿病患者（伴种植体周围炎 39 例，不伴种植体周围炎 52 例；组 1）。80 个种植体植入糖尿病患者（伴种植体周围炎 35 例，不伴种植体周围炎 45 例；组 2）。测量种植体周围菌斑指数、探诊出血、探诊深度和边缘骨丧失。采集非刺激性全唾液样本，使用标准技术测量 IL-1β 和 IL-6 水平。p<0.05 被认为具有统计学意义。
结果
在组 1 中，伴种植体周围炎患者的菌斑指数（p<0.001）、探诊出血（p<0.001）、探诊深度（p<0.001）以及全唾液 IL-1β（p<0.001）和 IL-6（p<0.001）水平显著高于不伴种植体周围炎患者。组 2 中所有患者的菌斑指数、探诊出血、探诊深度和边缘骨丧失均无差异。伴种植体周围炎的患者中，糖尿病患者的菌斑指数（p<0.001）、探诊出血（p<0.001）、探诊深度（p<0.001）、边缘骨丧失（p<0.001）以及全唾液 IL-1β（p<0.001）和 IL-6（p<0.001）水平显著高于非糖尿病患者。
结论
在无糖尿病患者中，伴种植体周围炎患者的种植体周围菌斑指数、探诊出血、探诊深度、边缘骨丧失以及全唾液 IL-1β 和 IL-6 水平高于不伴种植体周围炎患者。在糖尿病患者中，测量参数的严重程度似乎受血糖状态的影响，而不是种植体周围炎的影响。
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