亚铁螯合肽激动剂作为治疗工具。
Hepcidin agonists as therapeutic tools.
机构信息
Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; and.
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
出版信息
Blood. 2018 Apr 19;131(16):1790-1794. doi: 10.1182/blood-2017-11-737411. Epub 2018 Mar 9.
Abstract
Hepcidin agonists are a new class of compounds that regulate blood iron levels, limit iron absorption, and could improve the treatment of hemochromatosis, β-thalassemia, polycythemia vera, and other disorders in which disrupted iron homeostasis causes or contributes to disease. Hepcidin agonists also have the potential to prevent severe complications of siderophilic infections in patients with iron overload or chronic liver disease. This review highlights the preclinical studies that support the development of hepcidin agonists for the treatment of these disorders.
摘要
亚铁整合素激动剂是一类新的化合物，可调节血液中铁的水平，限制铁的吸收，并可能改善血色病、β-地中海贫血、真性红细胞增多症和其他铁稳态失调导致或促成疾病的疾病的治疗。亚铁整合素激动剂还有可能预防铁过载或慢性肝病患者中噬铁菌感染的严重并发症。本综述强调了支持开发亚铁整合素激动剂治疗这些疾病的临床前研究。
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