Sugiyama Yoko, Iida Hiroki, Amaya Fumimasa, Matsuo Kanako, Matsuoka Yutaka, Kojima Keiko, Matsuno Fumitaka, Hamaguchi Takayuki, Iseki Masako, Yamaguchi Keisuke, Takahashi Yoshika, Hara Atsuko, Sugasawa Yusuke, Kawamata Mikito, Tanaka Satoshi, Inagaki Yoshimi, Otsuki Akihiro, Yamazaki Mitsuaki, Ito Hisakatsu
Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan.
Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
J Anesth. 2018 Jun;32(3):434-438. doi: 10.1007/s00540-018-2481-0. Epub 2018 Mar 9.
We performed a multicenter observational study to assess the prevalence and risk factors of persistent pain after lung cancer surgery and total knee arthroplasty (TKA) in the Japanese population. After receiving Ethics Committee approval, a retrospective chart review was performed for patients who underwent surgery at seven university hospitals in Japan in 2013. A total of 511 patients who underwent lung cancer surgery and 298 patients who underwent TKA were included. The prevalence of chronic postsurgical pain (CPSP) at 3 and 6 months was 18 and 12% after lung surgery and 49 and 33% after TKA, respectively. The prevalence of analgesic use at 3 and 6 months was 16 and 9% after lung surgery and 34 and 22% after TKA, respectively. In both groups, preoperative analgesic use was associated with CPSP. Anesthetic methods or techniques during both types of surgery did not significantly affect the prevalence of CPSP. This is the first study in which the prevalence of CPSP after lung surgery and TKA in Japanese population was extensively evaluated in a multicenter trial. Further prospective studies are needed to confirm the prevalence of CPSP in the Japanese population and to identify risk factors and prevention methods.
我们开展了一项多中心观察性研究,以评估日本人群肺癌手术和全膝关节置换术(TKA)后持续性疼痛的患病率及危险因素。在获得伦理委员会批准后,对2013年在日本七所大学医院接受手术的患者进行了回顾性病历审查。共纳入511例行肺癌手术的患者和298例行TKA的患者。肺癌手术后3个月和6个月慢性术后疼痛(CPSP)的患病率分别为18%和12%,TKA后分别为49%和33%。肺癌手术后3个月和6个月使用镇痛药的患病率分别为16%和9%,TKA后分别为34%和22%。在两组中,术前使用镇痛药均与CPSP相关。两种手术期间的麻醉方法或技术对CPSP的患病率无显著影响。这是第一项在多中心试验中广泛评估日本人群肺癌手术和TKA后CPSP患病率的研究。需要进一步开展前瞻性研究,以确认日本人群中CPSP的患病率,并确定危险因素和预防方法。