共病数量对2型糖尿病患者全因死亡率和血糖结局的影响：一项系统评价方案

Impact of multimorbidity count on all-cause mortality and glycaemic outcomes in people with type 2 diabetes: a systematic review protocol.

作者信息

Chiang Jason I, Furler John, Mair Frances S, Jani Bhautesh, Nicholl Barbara I, Jenkins Alicia, Condron Patrick, O'Neal David, Manski-Nankervis Jo-Anne

机构信息

Department of General Practice, University of Melbourne, Melbourne, Victoria, Australia.

General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.

出版信息

BMJ Open. 2018 Apr 5;8(4):e021100. doi: 10.1136/bmjopen-2017-021100.

DOI:10.1136/bmjopen-2017-021100

PMID:29626050

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5892751/

Abstract

INTRODUCTION

Type 2 diabetes (T2D) is a leading health priority worldwide. Multimorbidity (MM) is a term describing the co-occurrence of two or more chronic diseases or conditions. The majority of people living with T2D have MM. The relationship between MM and mortality and glycaemia in people with T2D is not clear.

METHODS AND ANALYSIS

Medline, Embase, Cumulative Index of Nursing and Allied Health Complete, The Cochrane Library, and SCOPUS will be searched with a prespecified search strategy. The searches will be limited to quantitative empirical studies in English with no restriction on publication date. One reviewer will perform title screening and two review authors will independently screen the abstract and full texts using Covidence software, with disagreements adjudicated by a third reviewer. Data will be extracted using a using a Population, Exposure, Comparator and Outcomes framework. Two reviewers will independently extract data and undertake the risk of bias (quality) assessment. Disagreements will be resolved by consensus. A narrative synthesis of the results will be conducted and meta-analysis considered if appropriate. Quality appraisal will be undertaken using the Newcastle-Ottawa quality assessment scale and the quality of the cumulative evidence of the included studies will be assessed using the Grading of Recommendations, Assessment, Development and Evaluation approach. This protocol was prepared in adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines to ensure the quality of our review.

ETHICS AND DISSEMINATION

This review will synthesise the existing evidence about the impact of MM on mortality and glycaemic outcomes in people living with T2D and increase our understanding of this subject and will inform future practice and policy. Findings will be disseminated via conference presentations, social media and peer-reviewed publication.

PROSPERO REGISTRATION NUMBER

CRD42017079500.

摘要

引言

2型糖尿病（T2D）是全球首要的健康问题。多病共存（MM）是一个描述两种或更多慢性疾病或病症同时出现的术语。大多数T2D患者都患有多病共存。T2D患者中多病共存与死亡率及血糖之间的关系尚不清楚。

方法与分析

将使用预先指定的检索策略对医学期刊数据库（Medline）、荷兰医学文摘数据库（Embase）、护理学与健康相关领域累积索引数据库（Cumulative Index of Nursing and Allied Health Complete）、考克兰图书馆（The Cochrane Library）和Scopus数据库进行检索。检索将限于英文的定量实证研究，对发表日期无限制。一名评审员将进行标题筛选，两名综述作者将使用Covidence软件独立筛选摘要和全文，如有分歧则由第三名评审员裁决。将使用人群、暴露因素、对照和结局框架提取数据。两名综述作者将独立提取数据并进行偏倚风险（质量）评估。分歧将通过协商解决。将对结果进行叙述性综合分析，并在适当情况下考虑进行荟萃分析。将使用纽卡斯尔-渥太华质量评估量表进行质量评估，并使用推荐分级、评估、制定与评价方法评估纳入研究的累积证据质量。本方案是按照系统评价与荟萃分析方案的首选报告项目指南编写的，以确保我们综述的质量。