环境丰富后增强的突触可塑性的 RNA 依赖性代际遗传。
RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment.
机构信息
Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Strasse 3A, 37075 Göttingen, Germany.
Trans-synaptic Signaling Group, European Neuroscience Institute, Grisebachstrasse 5, 37077 Göttingen, Germany.
出版信息
Cell Rep. 2018 Apr 10;23(2):546-554. doi: 10.1016/j.celrep.2018.03.059.
Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer's disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that this effect is mediated through sperm RNA and especially miRs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific miRs as candidates mechanistically involved in this type of transmission.
体育锻炼与认知训练相结合已被证实可增强突触可塑性、学习和记忆，并降低包括阿尔茨海默病在内的多种复杂疾病的风险。在这里，我们发现成年雄性小鼠暴露于环境丰富模型中，可使后代的突触可塑性和认知能力增强。我们发现这种效应是通过精子 RNA 介导的，特别是 miR212/132。总之，本研究报告了获得性认知益处的跨代遗传，并指出特定的 microRNAs 可能是这种传递的机制性候选物。
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