α2,3-连接的唾液酸化在透明细胞型上皮性卵巢癌中的作用。

The role of α2,3-linked sialylation on clear cell type epithelial ovarian cancer.

作者信息

Sung Pi-Lin, Wen Kuo-Chang, Horng Huann-Cheng, Chang Chia-Ming, Chen Yi-Jen, Lee Wen-Ling, Wang Peng-Hui

机构信息

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei, Taiwan.

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan; Institute of BioMedical Informatics, National Yang-Ming University, Taipei, Taiwan.

出版信息

Taiwan J Obstet Gynecol. 2018 Apr;57(2):255-263. doi: 10.1016/j.tjog.2018.02.015.

DOI:10.1016/j.tjog.2018.02.015

PMID:29673670

Abstract

OBJECTIVE

Our previous study has shown that high expression of α2,3-sialytransferase type I was associated with advanced stage serous type epithelial ovarian cancer (EOC). The aim of the current study further attempts to evaluate the altered α 2,3-sialylation on the behavior of clear cell type EOC (C-EOC).

MATERIALS AND METHODS

Immunohistochemistry staining, bioinformatics analysis and tissue array were used to disclose the clinical significance of over α2,3-sialylation in C-EOC. An α2,3 sialylation inhibitor, soyasaponin I (SsaI) was used to investigate the behavior change of the C-EOC cell line.

RESULTS

We reconfirmed that α2,3-sialylation, instead of α2,6- sialylation, was associated with late-stage C-EOC. Soyasaponin I could inhibit α2,3-sialylation of C-EOC cell lines and increase E-cadherin expression with subsequently suppressing migration of C-EOC cells.

CONCLUSIONS

The current study demonstrated the important role of α2,3-linked sialylation in C-EOC and targeting of α2,3-linked sialylation might offer as a potential therapeutic strategy in the future.

摘要