半夏泻心汤治疗胃食管反流病：一项对照试验系统评价方案
Banxia Xiexin tang for gastro-oesophageal reflux disease: A protocol for a systematic review of controlled trials.
作者信息
Kang Bohyung, Lee Haesol, Choi Youkyung, Jeon Chanyong, Lee Ju Ah
机构信息
Department of Korean Internal Medicine, College of Korean Medicine, Gachon University.
出版信息
Medicine (Baltimore). 2018 Apr;97(17):e0393. doi: 10.1097/MD.0000000000010393.
BACKGROUND
Gastrooesophageal reflux disease (GORD) is one of the most common gastrointestinal diseases encountered in clinical practice. The aim of the present study is thus to systematically review the literature, including Asian studies, to assess the efficacy and safety of Banxia Xiexin tang (BXT) for the treatment of GORD.
METHODS AND ANALYSIS
Eleven databases will be searched for studies conducted through March 2018. We will include randomized controlled trials (RCTs) of BXT as a treatment for GORD. All RCTs on BXT or related formulations will be included. The risk of bias will be assessed using the Cochrane Risk of Bias Assessment Tool, while confidence in the cumulative evidence will be evaluated using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) tool.
ETHICS AND DISSEMINATION
This systematic review will be published in a peer-reviewed journal and will also be disseminated electronically and in print. The review will be updated to inform and guide healthcare practices.
REGISTRATION NUMBER
CRD42018087056.
背景
胃食管反流病（GORD）是临床实践中最常见的胃肠道疾病之一。因此，本研究的目的是系统回顾文献，包括亚洲地区的研究，以评估半夏泻心汤（BXT）治疗GORD的有效性和安全性。
方法与分析
将检索11个数据库，查找截至2018年3月开展的研究。我们将纳入BXT治疗GORD的随机对照试验（RCT）。所有关于BXT或相关制剂的RCT均将纳入。将使用Cochrane偏倚风险评估工具评估偏倚风险，同时使用推荐分级、评估、制定与评价（GRADE）工具评估累积证据的可信度。
伦理与传播
本系统评价将发表在同行评审期刊上，也将以电子和印刷形式传播。该评价将进行更新，为医疗实践提供信息和指导。
注册号
CRD42018087056。
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