三结构域蛋白精确并积极地影响宿主抗病毒免疫反应。

Tripartite motif-containing proteins precisely and positively affect host antiviral immune response.

机构信息

Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.

Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan, China.

出版信息

Scand J Immunol. 2018 Jun;87(6):e12669. doi: 10.1111/sji.12669.

DOI:10.1111/sji.12669

PMID:29706026

Abstract

The tripartite motif-containing proteins (TRIMs) comprise a large family of proteins with over 70 members in humans. Recent studies have shown that TRIMs play unexpected roles in the antiviral immune responses to infections by HIV, MLV, EMCV, AIV and other viruses. There are two mechanisms used by TRIMs in the inhibition of virus infections: (1) TRIMs target the produced viruses for ubiquitination, which induces proteasome-dependent degradation, or they interact with host proteins to inhibit viral infection in various periods of the viral life cycle. (2) TRIMs activate innate immune signalling pathways, such as RLR and TLR, which induce IFN production. In this study, we will review recent studies regarding the means by which TRIMs function as inhibitors in viral infection through the mechanisms described above.

摘要

三结构域蛋白（TRIMs）包含一个大型蛋白家族，人类中该家族有超过 70 个成员。最近的研究表明，TRIMs 在 HIV、MLV、EMCV、AIV 和其他病毒感染的抗病毒免疫反应中发挥了意想不到的作用。TRIMs 有两种抑制病毒感染的机制：（1）TRIMs 将产生的病毒作为泛素化的靶标，诱导蛋白酶体依赖性降解，或者它们与宿主蛋白相互作用，以在病毒生命周期的各个时期抑制病毒感染。（2）TRIMs 激活先天免疫信号通路，如 RLR 和 TLR，诱导 IFN 的产生。在本研究中，我们将综述最近的研究，探讨上述机制下 TRIMs 作为病毒感染抑制剂的作用方式。